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Enhancing in Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Via Sustained Dexamethasone Delivery in 3D-Printed Hybrid Scaffolds Based on Polycaprolactone-Nanohydroxyapatite/Alginate-Gelatin for Bone Regeneration Publisher



Noory P1 ; Farmani AR2 ; Ai J1 ; Bahrami N1, 3 ; Bayat M3 ; Ebrahimibarough S1 ; Farzin A4 ; Shojaie S5 ; Hajmoradi H6 ; Mohamadnia A7, 8 ; Goodarzi A2
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Material Engineering Department, Faculty of Engineering, Tarbiat Modares University, Tehran, Iran
  5. 5. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Biological Engineering Published:2025


Abstract

Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel). 3D-printing scaffolds were used to control the delivery of dexamethasone (DEX) to enhance bone repair. DEX-loaded scaffolds promoted osteogenic differentiation and mineralization of human endometrial mesenchymal stem cells (hEnMSCs). © The Author(s) 2025.
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