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Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine Publisher



Farmani AR1, 2, 3 ; Salmeh MA4 ; Golkar Z5 ; Moeinzadeh A6, 7 ; Ghiasi FF6 ; Amirabad SZ8 ; Shoormeij MH9 ; Mahdavinezhad F10, 11 ; Momeni S12 ; Moradbeygi F13, 14 ; Ai J1 ; Hardy JG15, 16 ; Mostafaei A17
Authors
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Authors Affiliations
  1. 1. Tissue Engineering and Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 14166-34793, Iran
  2. 2. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, 74615-168, Iran
  3. 3. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, 14166-34793, Iran
  4. 4. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 14155-6619, Iran
  5. 5. Department of Midwifery, Firoozabad Branch, Islamic Azad University, Firoozabad, 74715-117, Iran
  6. 6. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
  7. 7. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
  8. 8. Department of Chemical Engineering, Faculty of Engineering, Yasouj University, Yasouj, 75918-74934, Iran
  9. 9. Emergency Medicine Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 14166-34793, Iran
  10. 10. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, 14166-34793, Iran
  11. 11. Department of Infertility, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, 34199-15315, Iran
  12. 12. Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 83151-61355, Iran
  13. 13. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran
  14. 14. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran
  15. 15. Department of Chemistry, Faraday Building, Lancaster University, Lancaster, LA1 4YB, United Kingdom
  16. 16. Materials Science Institute, Lancaster University, Lancaster, LA1 4YW, United Kingdom
  17. 17. Department of Mechanical, Materials, and Aerospace Engineering, Illinois Institute of Technology, 10 W 32nd Street, Chicago, 60616, IL, United States

Source: Journal of Functional Biomaterials Published:2022


Abstract

Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future. © 2022 by the authors.
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