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Fabricating Alginate/Poly(Caprolactone) Nanofibers With Enhanced Bio-Mechanical Properties Via Cellulose Nanocrystal Incorporation Publisher Pubmed



Rashtchian M1 ; Hivechi A1 ; Bahrami SH1 ; Milan PB2, 3, 4 ; Simorgh S2
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Authors Affiliations
  1. 1. Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran
  2. 2. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Institute of Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Carbohydrate Polymers Published:2020


Abstract

In this research, cellulose nanocrystal (CNC) was synthesized from cotton waste using controlled hydrolysis against 64 % (w/w) sulfuric acid solution. The produced nanoparticles were then characterized using FTIR, XRD, TGA, and DLS analyses. Biaxial electrospinning technique was used to produce CNC incorporated PCL-PVA/NaAlg nanofibers. The sodium alginate portion was then crosslinked via submerging the samples in calcium chloride aqueous solution. The CNC incorporated and crosslinked sample was characterized using SEM, FTIR, and TGA techniques. Results confirmed the presence of CNC nanoparticles and alginate crosslinking reaction. Mechanical studies showed that CNC incorporation increases the tensile modulus by 65 %. Also, the crosslinked samples exhibited an increase in elongation at break. Water contact angle studies suggested that CNC incorporation and crosslinking improves nanofiber hydrophilicity. Cell viability of more than 90 % was observed in CNC incorporated PCL-CaAlg nanofibers. Also, SEM images of cells on nanofiber scaffolds showed better cell growth and attachment in PCL-CaAlg-CNC samples. © 2020 Elsevier Ltd
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