Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Silk Fibroin/Hydroxyapatite Composites for Bone Tissue Engineering Publisher Pubmed



Farokhi M1 ; Mottaghitalab F2 ; Samani S3 ; Shokrgozar MA1 ; Kundu SC4 ; Reis RL4 ; Fatahi Y5 ; Kaplan DL6
Authors
Show Affiliations
Authors Affiliations
  1. 1. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering & Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. 3Bs Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Barco, 4805-017, Guimaraes, Portugal
  5. 5. Department of pharmaceutical nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, 02155, MA, United States

Source: Biotechnology Advances Published:2018


Abstract

Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applications for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-established bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes. However, HAp ceramics tend to be brittle which can restrict applications in the repair of load-bearing tissues such as bones. Therefore, blending SF and HAp combines the useful properties of both materials as bone constructs for tissue engineering, the subject of this review. © 2017 Elsevier Inc.
Related Docs
View other Related Docs
1. Silk As a Potential Candidate for Bone Tissue Engineering, Journal of Controlled Release (2015)
2. Silk Fibroin Scaffolds for Common Cartilage Injuries: Possibilities for Future Clinical Applications, European Polymer Journal (2019)
3. Prospects of Peripheral Nerve Tissue Engineering Using Nerve Guide Conduits Based on Silk Fibroin Protein and Other Biopolymers, International Materials Reviews (2017)
4. Functionalized Silk Fibroin Nanofibers As Drug Carriers: Advantages and Challenges, Journal of Controlled Release (2020)
5. Preparation of a Codelivery System Based on Vancomycin/Silk Scaffold Containing Silk Nanoparticle Loaded Vegf, ACS Biomaterials Science and Engineering (2018)
6. Sustainable Release of Vancomycin From Silk Fibroin Nanoparticles for Treating Severe Bone Infection in Rat Tibia Osteomyelitis Model, ACS Applied Materials and Interfaces (2017)
7. Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy, ACS Applied Materials and Interfaces (2017)
8. Silk Fibroin Nanoparticle As a Novel Drug Delivery System, Journal of Controlled Release (2015)
Experts (# of related papers)
View all Related Experts
Fatameh Mottaghitalab (21)
Fatemeh Atyabi (12)
Other Related Docs
9. Importance of Dual Delivery Systems for Bone Tissue Engineering, Journal of Controlled Release (2016)
10. Recent Trends in Controlled Drug Delivery Based on Silk Platforms, Silk-Based Biomaterials for Tissue Engineering# Regenerative# and Precision Medicine# 2nd Edition (2023)
11. Prospects of Sirna Applications in Regenerative Medicine, International Journal of Pharmaceutics (2017)
12. Overview of Silk Fibroin Use in Wound Dressings, Trends in Biotechnology (2018)
13. Silk Fibroin/Alumina Nanoparticle Scaffold Using for Osteogenic Differentiation of Rabbit Adipose-Derived Stem Cells, Materialia (2020)
14. Dual Drug Delivery System of Teicoplanin and Phenamil Based on Ph-Sensitive Silk Fibroin/Sodium Alginate Hydrogel Scaffold for Treating Chronic Bone Infection, Biomaterials Advances (2022)
15. Dual Drug Delivery System Based on Ph-Sensitive Silk Fibroin/Alginate Nanoparticles Entrapped in Pnipam Hydrogel for Treating Severe Infected Burn Wound, Biofabrication (2020)
16. Status and Future Scope of Plant-Based Green Hydrogels in Biomedical Engineering, Applied Materials Today (2019)
17. In Vitro Study of a Novel Multi-Substituted Hydroxyapatite Nanopowder Synthesized by an Ultra-Fast, Efficient and Green Microwave-Assisted Method, Materials Science and Engineering C (2020)
18. Investigation of Properties of Chemically Cross-Linked Silk Nanofibrous Mat As a Nerve Guide, Materials Technology (2017)
19. Biomedical Applications of Silkworm (Bombyx Mori) Proteins in Regenerative Medicine (A Narrative Review), Journal of Tissue Engineering and Regenerative Medicine (2022)
20. Comparative Repair Capacity of Knee Osteochondral Defects Using Regenerated Silk Fiber Scaffolds and Fibrin Glue With/Without Autologous Chondrocytes During 36 Weeks in Rabbit Model, Cell and Tissue Research (2016)
21. Endothelial and Osteoblast Differentiation of Adipose-Derived Mesenchymal Stem Cells Using a Cobalt-Doped Cap/Silk Fibroin Scaffold, ACS Biomaterials Science and Engineering (2019)
22. The Effect of Fibronectin Coating on Protein Corona Structure and Cellular Uptake of Single-Walled Carbon Nanotubes, Precision Nanomedicine (2020)
23. Incorporation of Spion-Casein Core-Shells Into Silk-Fibroin Nanofibers for Cardiac Tissue Engineering, Journal of Cellular Biochemistry (2020)
24. A Comparison Study on the Behavior of Human Endometrial Stem Cell-Derived Osteoblast Cells on Plga/Ha Nanocomposite Scaffolds Fabricated by Electrospinning and Freeze-Drying Methods, Journal of Orthopaedic Surgery and Research (2018)
25. Combination Therapy of Breast Cancer by Codelivery of Doxorubicin and Survivin Sirna Using Polyethylenimine Modified Silk Fibroin Nanoparticles, ACS Biomaterials Science and Engineering (2021)
26. Application of Nanomaterials in Three-Dimensional Stem Cell Culture, Journal of Cellular Biochemistry (2019)
27. Tissue Engineering: Still Facing a Long Way Ahead, Journal of Controlled Release (2018)
28. Vascular Endothelial Growth Factor (Vegf) Delivery Approaches in Regenerative Medicine, Biomedicine and Pharmacotherapy (2023)
29. Nanotopographical Cues of Electrospun Plla Efficiently Modulate Non-Coding Rna Network to Osteogenic Differentiation of Mesenchymal Stem Cells During Bmp Signaling Pathway, Materials Science and Engineering C (2018)
30. Electrospun Nerve Guide Scaffold of Poly(Ε-Caprolactone)/Collagen/Nanobioglass: An in Vitro Study in Peripheral Nerve Tissue Engineering, Journal of Biomedical Materials Research - Part A (2017)
31. Effects of the Biological Environment on Ceramics: Degradation, Cell Response, and in Vivo Behavior, Fundamental Biomaterials: Ceramics (2018)
32. Tuning the Conformation and Mechanical Properties of Silk Fibroin Hydrogels, European Polymer Journal (2020)
33. In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration, Artificial Cells# Nanomedicine and Biotechnology (2018)
34. Optimized Composition of Nanocomposite Scaffolds Formed From Silk Fibroin and Nano-Tio2 for Bone Tissue Engineering, Materials Science and Engineering C (2017)
35. Novel Fluoridated Silk Fibroin/ Tio2 Nanocomposite Scaffolds for Bone Tissue Engineering, Materials Science and Engineering C (2018)
36. Conductive Hydrogels Based on Tragacanth and Silk Fibroin Containing Dopamine Functionalized Carboxyl-Capped Aniline Pentamer: Merging Hemostasis, Antibacterial, and Anti-Oxidant Properties Into a Multifunctional Hydrogel for Burn Wound Healing, International Journal of Biological Macromolecules (2024)
37. Bioactive Glasses Entering the Mainstream, Drug Discovery Today (2018)
38. Bone Regeneration in Rat Using a Gelatin/Bioactive Glass Nanocomposite Scaffold Along With Endothelial Cells (Huvecs), International Journal of Applied Ceramic Technology (2018)
39. Chitosan-Intercalated Montmorillonite/Poly(Vinyl Alcohol) Nanofibers As a Platform to Guide Neuronlike Differentiation of Human Dental Pulp Stem Cells, ACS Applied Materials and Interfaces (2017)
40. Cells, Scaffolds and Their Interactions in Myocardial Tissue Regeneration, Journal of Cellular Biochemistry (2017)
41. Development of a Biomimetic Peptide-Based Nanoformulation Against the Breast Cancer, Acta Medica Iranica (2021)
42. Sequential Application of Mineralized Electroconductive Scaffold and Electrical Stimulation for Efficient Osteogenesis, Journal of Biomedical Materials Research - Part A (2018)
43. Nanocomposite Scaffold Seeded With Mesenchymal Stem Cells for Bone Repair, Cell Biology International (2019)
44. Facile Synthesis of Biphasic Calcium Phosphate Microspheres With Engineered Surface Topography for Controlled Delivery of Drugs and Proteins, Colloids and Surfaces B: Biointerfaces (2017)
45. Silver- and Fluoride-Containing Mesoporous Bioactive Glasses Versus Commonly Used Antibiotics: Activity Against Multidrug-Resistant Bacterial Strains Isolated From Patients With Burns, Burns (2016)
46. Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineerings, Materials (2020)
47. Drug Loading and Delivery Using Nanofibers Scaffolds, Artificial Cells# Nanomedicine and Biotechnology (2017)
48. Conductive Biomaterials As Nerve Conduits: Recent Advances and Future Challenges, Applied Materials Today (2020)
49. Theranostic Silk Sericin/Spion Nanoparticles for Targeted Delivery of Ror1 Sirna: Synthesis, Characterization, Diagnosis and Anticancer Effect on Triple-Negative Breast Cancer, International Journal of Biological Macromolecules (2022)
50. In Vitro Osteogenic Differentiation Potential of the Human Induced Pluripotent Stem Cells Augments When Grown on Graphene Oxide-Modified Nanofibers, Gene (2019)