Harnessing the Anti-Inflammatory Effects of Perinatal Tissue Derived Therapies for the Treatment of Inflammatory Skin Diseases: A Comprehensive Review Publisher Pubmed



Khalilzad MA^{1, 2, 3} ; Mohammadi J¹ ; Najafi S^{7, 8} ; Amirsaadat S⁹ ; Zare S^{2, 4, 5, 6} ; Khalilzad M¹⁰ ; Shamloo A⁶ ; Khaghani A¹¹ ; Peyrovan A² ; Khalili SFS² ; Fayyaz N² ; Zare S^{2, 4, 5, 6} Show Affiliations
Source: Stem Cell Reviews and Reports Published:2025

Abstract

Dealing with chronic inflammatory skin conditions like atopic dermatitis and psoriasis can be extremely difficult. Current treatments, such as topical corticosteroids, often have limitations and side effects. However, researchers have discovered that the placenta’s remarkable properties may provide a breakthrough in effectively addressing these skin conditions. The placenta comprises three essential tissues: decidua, placental membrane, and umbilical cord. Placental derivatives have shown significant potential in treating psoriasis by reducing inflammatory cytokines and inhibiting keratinocyte proliferation. In the case of atopic dermatitis, umbilical cord stem cells have demonstrated anti-inflammatory effects by targeting critical factors and promoting anti-inflammatory cytokines. The scope of benefits associated with placental derivatives transcends these specific applications. They also potentially address other inflammatory skin diseases, such as vitiligo, by stimulating melanin production. Moreover, these derivatives have been leveraged in the treatment of pemphigus and epidermolysis bullosa (EB), showcasing potential as a wound dressing that could eliminate the necessity for painful dressing changes in EB patients. In summary, the integration of placental derivatives stands to revolutionize our approach to inflammatory skin conditions owing to their distinct properties and the prospective benefits they offer. This comprehensive review delves into the current applications of placental derivatives in addressing inflammatory skin diseases, presenting a novel treatment approach. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.