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Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing Publisher Pubmed



Khalilzad MA1, 2, 3 ; Mohammadi J1 ; Amirsaadat S7 ; Najafi S8, 9 ; Zare S2, 4, 5, 6 ; Nilforoushzadeh MA2, 10 ; Khalilzad M11 ; Khaghani A12 ; Soltankouhi MRF13 ; Hajimohammad A2
Authors
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Authors Affiliations
  1. 1. Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 143951561, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Laser application Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, Iran
  6. 6. Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran
  7. 7. Stem Cell Research Center, Tabriz university of medical sciences, Tabriz, Iran
  8. 8. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
  10. 10. Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran
  11. 11. Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Department of Gynecological Surgery, Tehranpars Hospital, Tehran, Iran
  13. 13. Department of Medical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran

Source: Stem Cell Reviews and Reports Published:2025


Abstract

Dermatologists have been interested in recent advancements in regenerative therapy. Current research is actively investigating the possibility of placental tissue derivatives to decelerate the skin aging process, enhance skin regeneration, reduce scarring, and prevent hair loss. Amniotic membranes (AM) play a crucial role in regenerative medicine as they serve as a suitable means of transporting stem cells, growth hormones, cytokines, and other essential compounds. Regulating an intricate network of biological processes improves the development and repair of tissues. Studies done by dermatologists indicate that several compounds found in the decidua, umbilical cord, and amniotic membrane have the potential to be used for regeneration. Examples include mesenchymal stem cells, growth factors, and immunomodulatory pharmaceuticals. Due to research and technological developments, scientists may use placental sections to facilitate skin regeneration, minimize scarring, and expedite wound healing. This study examines the current state of dermatological therapy, with a focus on using derivatives obtained from fetal tissue as the basis. The critical areas of study focus on this strategy are the potential benefits, growth opportunities, and recovery rates. Based on a thorough examination of the available literature and clinical data, we want to make definitive conclusions on the possible influence of fetal tissue derivatives in dermatological therapy. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.