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Coenzyme Q10 Attenuates Neurodegeneration in the Cerebellum Induced by Chronic Exposure to Tramadol Publisher Pubmed



Keyhanifard M1, 2, 3 ; Javan R4 ; Disfani RA5 ; Bahrami M6 ; Mirzaie MS7 ; Taghiloo S8 ; Mokhtari H9 ; Nasiry D9 ; Sadrzadeh Aghajani Z10 ; Shooraj M11
Authors
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Authors Affiliations
  1. 1. Iranian Board of Neurology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Kurdistan Board of Neurology, Iraq
  3. 3. Fellowship of Interventional Neuroradiology, Zurich University, Switzerland
  4. 4. Non-Comunicable Disease Risearch Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  5. 5. Student Research Committee, Sabzevar University of Medical Science, Sabzevar, Iran
  6. 6. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Physiotherapy, Faculty of Rehabilitation Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  9. 9. Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
  10. 10. School of Pharmacology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
  11. 11. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Source: Journal of Chemical Neuroanatomy Published:2024


Abstract

Background: Chronic use of tramadol can cause neurotoxic effects and subsequently cause neurodegeneration in the cerebellum. The main damage mechanisms identified are oxidative stress and inflammation. Currently, we investigated the effects of coenzyme Q10 (CoQ10) in attenuates of neurodegeneration in the cerebellum induced by chronic exposure to tramadol. Material and methods: Seventy-two male mature albino rats were allocated into four equal groups, including; non-treated group, CoQ10 group (which received CoQ10 at 200 mg/kg/day orally for three weeks), tramadol group (which received tramadol hydrochloride at 50 mg/kg/day orally for three weeks), and tramadol+CoQ10 group (which received tramadol and CoQ10 at the same doses as the previous groups). Tissue samples were obtained for stereological, immunohistochemical, biochemical, and molecular evaluations. Also, functional tests were performed to evaluate behavioral properties. Results: We found a significant increase in stereological parameters, antioxidant factors (catalase, glutathione, and superoxide dismutase), and behavioral function scores in the tramadol+CoQ10 group compared to the tramadol group (p < 0.05). In addition, malondialdehyde levels, the density of apoptotic cells, as well as the expression of pro-inflammatory (tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6) and autophagy (lysosome-associated membrane protein 2, autophagy-related 5, beclin 1, and autophagy-related 12) genes were considerably reduced in the tramadol+CoQ10 group compared to the tramadol group (p < 0.05). Conclusion: We conclude that the administration of CoQ10 has neuroprotective effects in the cerebellum of rats that have chronic exposure to tramadol. © 2023 Elsevier B.V.
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