Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity

Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity Publisher

Farhood B¹ ; Abtahi SMM² ; Geraily G¹ ; Ghorbani M³ ; Mahdavi SR⁴ ; Zahmatkesh MH⁵

Show Affiliations

1. Medical Physics and Medical Engineering Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Physics Department, Imam Khomeini International University, Qazvin, Iran
3. Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
5. Health Physics Department, University of Shahid Beheshti, Tehran, Iran

Source: Radiation Physics and Chemistry Published:2018

Abstract

Despite many advantages of polymer gel dosimeters, their clinical use is only not realized now. Toxicity of polymer gel dosimeters can be considered as one of their main limitations for use in routine clinical applications. In the current study, a new polymer gel dosimeter is introduced with negligible toxicity. For this purpose, 2-Acrylamido-2-Methy-1-PropaneSulfonic acid (AMPS) sodium salt monomer was replaced instead of acrylamide monomer used in PAGAT gel dosimeter by using %6 T and %50 C to the gel formula and the new formulation is called PASSAG (Poly AMPS Sodium Salt and Gelatin) polymer gel dosimeter. The irradiation of gel dosimeters was carried out using a Co-60 therapy machine. MRI technique was used to quantify the dose responses of the PASSAG gel dosimeter. Then, the MRI responses (R2) of the gel dosimeter was analyzed at different dose values, post-irradiation times, and scanning temperatures. The results showed that the new gel formulation has a negligible toxicity and it is also eco-friendly. In addition, carcinogenicity and genetic toxicity tests are negative for the monomer used in PASSAG. The radiological properties of PASSAG gel dosimeter showed that this substance can be considered as a soft tissue/water equivalent material. Furthermore, dosimetric evaluation of the new polymer gel dosimeter revealed an excellent linear R2-dose response in the evaluated dose range (0–15 Gy). The R2-dose sensitivity and dose resolution of PASSAG gel dosimeter were 0.081 s−1Gy−1 (in 0–15 Gy dose range) and 1 Gy (in 0–10 Gy dose range), respectively. Moreover, it was shown that the R2-dose sensitivity and dose resolution of the new gel dosimeter improves over time after irradiation. It was also found that the R2 response of the PASSAG gel dosimeter has less dependency to the 18, 20, and 24 °C scanning temperature in comparison to that of room temperature (22 °C). © 2018 Elsevier Ltd

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Style	Citing Format
MLA	Farhood B, et al.. "Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity." Radiation Physics and Chemistry, vol. 147, no. , 2018, pp. 91-100.
APA	Farhood B, Abtahi SMM, Geraily G, Ghorbani M, Mahdavi SR, Zahmatkesh MH (2018). Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity. Radiation Physics and Chemistry, 147(), 91-100.
Chicago	Farhood B, Abtahi SMM, Geraily G, Ghorbani M, Mahdavi SR, Zahmatkesh MH. "Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity." Radiation Physics and Chemistry 147, no. (2018): 91-100.
Harvard	Farhood B et al. (2018) 'Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity', Radiation Physics and Chemistry, 147(), pp. 91-100.
Vancouver	Farhood B, Abtahi SMM, Geraily G, Ghorbani M, Mahdavi SR, Zahmatkesh MH. Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity. Radiation Physics and Chemistry. 2018;147():91-100.
BibTex	@article{ author = {Farhood B and Abtahi SMM and Geraily G and Ghorbani M and Mahdavi SR and Zahmatkesh MH}, title = {Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity}, journal = {Radiation Physics and Chemistry}, volume = {147}, number = {}, pages = {91-100}, year = {2018} }
RIS	TY - JOUR AU - Farhood B AU - Abtahi SMM AU - Geraily G AU - Ghorbani M AU - Mahdavi SR AU - Zahmatkesh MH TI - Dosimetric Characteristics of Passag As a New Polymer Gel Dosimeter With Negligible Toxicity JO - Radiation Physics and Chemistry VL - 147 IS - SP - 91 EP - 100 PY - 2018 ER -

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