Quercetin and Polycystic Ovary Syndrome; Inflammation, Hormonal Parameters and Pregnancy Outcome: A Randomized Clinical Trial Publisher Pubmed



Vaez S¹ ; Parivr K¹ ; Amidi F^{2, 3} ; Rudbari NH¹ ; Moini A^{4, 5, 6} ; Amini N⁷
Source: American Journal of Reproductive Immunology Published:2023

Abstract

Problem: Women with PCOS have a reduced total antioxidant level in addition to higher oxidative stress. Quercetin is a flavonol-type antioxidant that may be found in many foods. Does quercetin affect inflammatory and hormonal factors and clinical outcomes in PCOS patients?. Method of Study: Seventy-two women with PCOS were randomly allocated to one of two intervention groups, and each received a daily dosage of 500 mg of Quercetin for the intervention group or a placebo for the control group for a period of 40 days from the start of the menstrual cycle until the day of ovulation. Serum levels of IL-6, TNF-alpha, LH, FSH, and AMH were measured using ELISA. In addition, oocyte and embryo grade before IVF and pregnancy rate have been examined. Results: LH levels reduce significantly in the quercetin group (4.351.62 at baseline to 3.061.43 after 3 months) (p =.029). The results indicated that Quercetin significantly decreased TNF alpha levels in comparison to the pretest (p =.008). Following capsule administration, IL-6 levels significantly decreased in the quercetin group (p =.001). Except for Δ LH, ΔIL6, and ΔFSH, there was no significant difference in any of the hormones and inflammations parameter changes. Conclusion: Quercetin consumption causes improvement in oocyte and embryo grade and the pregnancy rate in PCOS patients. As a result, regular consumption of Quercetin has been shown to decrease inflammatory and LH parameters, making it beneficial for the management of PCOS and related diseases. © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.