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A Review on the Role of M2 Macrophages in Bladder Cancer; Pathophysiology and Targeting Publisher Pubmed



Sharifi L1 ; Nowroozi MR1 ; Amini E1 ; Arami MK2 ; Ayati M1 ; Mohsenzadegan M3
Authors
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Authors Affiliations
  1. 1. Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Basic Sciences, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: International Immunopharmacology Published:2019


Abstract

Tumor-associated macrophages (TAMs) which are often referred to as immunosuppressive cells (M2 macrophage), constitute a subset of tumor microenvironment cells and affect tumor progression in solid tumors. Recently, these cells have gained remarkable importance as therapeutic candidates for solid tumors. In bladder cancer, major studies have focused on evaluating TAMs in response to Bacillus Calmette-Guerin (BCG) therapy. M2 macrophages may directly impact the BCG-induced immune responses against tumor in bladder cancer. They are the main inhibitors of the tumor microenvironment that promotes growth and metastasis of the tumor. However, the clinical significance of M2 macrophages in bladder cancer is controversial. In this review, we will discuss the clinical significance of M2 macrophages in prognosis of bladder cancer as well as worth of their potential targeting in bladder cancer treatment. In the following, we will introduce important factors resulting in M2 macrophage promotion and also experimental therapeutic agents that may cause the inhibition of bladder cancer tumor growth. © 2019 Elsevier B.V.
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