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The Complex Role of Macrophages in Pancreatic Cancer Tumor Microenvironment: A Review on Cancer Progression and Potential Therapeutic Targets Publisher



Lorestani P1 ; Dashti M2 ; Nejati N3 ; Habibi MA5 ; Askari M6 ; Robatjazi B7 ; Ahmadpour S8 ; Tavakolpour S9
Authors
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Authors Affiliations
  1. 1. Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Pediatric Cell and Gene Therapy Research Centre, Gene, Cell & amp
  4. 4. Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  7. 7. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  9. 9. Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02215, MA, United States

Source: Discover Oncology Published:2024


Abstract

Pancreatic cancer (PC) is one of the deadliest cancers worldwide with low survival rates and poor outcomes. The treatment landscape for PC is fraught with obstacles, including drug resistance, lack of effective targeted therapies and the immunosuppressive tumor microenvironment (TME). The resistance of PC to existing immunotherapies highlights the need for innovative approaches, with the TME emerging as a promising therapeutic target. The recent advancements in understanding the role of macrophages, this context highlight their significant impact on tumor development and progression. There are two important types of macrophages: M1 and M2, which play critical roles in the TME. Therapeutics strategies including, depletion of tumor-associated macrophages (TAMs), reprogramming TAMs to promote anti-tumor activity, and targeting macrophage recruitment can lead to promising outcomes. Targeting macrophage-related pathways may offer novel strategies for modulating immune responses, inhibiting angiogenesis, and overcoming resistance to chemotherapy in PC treatment. © The Author(s) 2024.
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