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Biological Macromolecule-Based Scaffolds for Urethra Reconstruction Publisher Pubmed



Farzamfar S1 ; Richer M1 ; Rahmani M2 ; Naji M3 ; Aleahmad M4 ; Chabaud S1 ; Bolduc S1, 5
Authors
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Authors Affiliations
  1. 1. Centre de Recherche en Organogenese Experimentale/LOEX, Regenerative Medicine Division, CHU de Quebec-Universite Laval Research Center, Quebec, G1V 4G2, QC, Canada
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran
  3. 3. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran
  4. 4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  5. 5. Department of Surgery, Faculty of Medicine, Laval University, Quebec, G1V 0A6, QC, Canada

Source: Biomolecules Published:2023


Abstract

Urethral reconstruction strategies are limited with many associated drawbacks. In this context, the main challenge is the unavailability of a suitable tissue that can endure urine exposure. However, most of the used tissues in clinical practices are non-specialized grafts that finally fail to prevent urine leakage. Tissue engineering has offered novel solutions to address this dilemma. In this technology, scaffolding biomaterials characteristics are of prime importance. Biological macromolecules are naturally derived polymers that have been extensively studied for various tissue engineering applications. This review discusses the recent advances, applications, and challenges of biological macromolecule-based scaffolds in urethral reconstruction. © 2023 by the authors.
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