Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma

Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma Publisher

Mansouri V¹ ; Arjmand B^{2, 3} ; Hamzeloomoghadam M⁴ ; Razzaghi Z⁵ ; Ahmadzadeh A¹ ; Ardakani MJE⁶ ; Robati RM⁷

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1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Iranian Cancer Control Center (MACSA), Tehran, Iran
4. Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine Shahid, Beheshti University of Medical Sciences, Tehran, Iran
5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2023

Abstract

Aim: Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study. Background: PDAC is known as an exocrine cancer with a 5-year overall survival of 11%. Methods: Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology. Results: Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 group of 52 biological terms were identified as the main affected terms. Conclusion: In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients. © 2023 Research Institute for Gastroenterology and Liver Diseases. All rights reserved.

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Babak Arjmand (1)

Style	Citing Format
MLA	Mansouri V, et al.. "Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma." Gastroenterology and Hepatology from Bed to Bench, vol. 16, no. 4, 2023, pp. 401-407.
APA	Mansouri V, Arjmand B, Hamzeloomoghadam M, Razzaghi Z, Ahmadzadeh A, Ardakani MJE, Robati RM (2023). Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma. Gastroenterology and Hepatology from Bed to Bench, 16(4), 401-407.
Chicago	Mansouri V, Arjmand B, Hamzeloomoghadam M, Razzaghi Z, Ahmadzadeh A, Ardakani MJE, Robati RM. "Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma." Gastroenterology and Hepatology from Bed to Bench 16, no. 4 (2023): 401-407.
Harvard	Mansouri V et al. (2023) 'Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma', Gastroenterology and Hepatology from Bed to Bench, 16(4), pp. 401-407.
Vancouver	Mansouri V, Arjmand B, Hamzeloomoghadam M, Razzaghi Z, Ahmadzadeh A, Ardakani MJE, et al.. Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma. Gastroenterology and Hepatology from Bed to Bench. 2023;16(4):401-407.
BibTex	@article{ author = {Mansouri V and Arjmand B and Hamzeloomoghadam M and Razzaghi Z and Ahmadzadeh A and Ardakani MJE and Robati RM}, title = {Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma}, journal = {Gastroenterology and Hepatology from Bed to Bench}, volume = {16}, number = {4}, pages = {401-407}, year = {2023} }
RIS	TY - JOUR AU - Mansouri V AU - Arjmand B AU - Hamzeloomoghadam M AU - Razzaghi Z AU - Ahmadzadeh A AU - Ardakani MJE AU - Robati RM TI - Extracellular Matrix Is the Main Targeted Environment in Early Stage of Pancreatic Ductal Adenocarcinoma JO - Gastroenterology and Hepatology from Bed to Bench VL - 16 IS - 4 SP - 401 EP - 407 PY - 2023 ER -

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