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Nucleic Acid-Responsive Smart Systems for Controlled Cargo Delivery Publisher Pubmed



Hasanzadeh A1, 2 ; Ebadati A1, 2, 3 ; Saeedi S2, 4 ; Kamali B1, 2 ; Noori H1, 2 ; Jamei B4 ; Hamblin MR5 ; Liu Y6 ; Karimi M1, 2, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Molecular and Cell Biology, University of California, Merced, Merced, United States
  4. 4. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
  6. 6. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
  7. 7. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  8. 8. Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Applied Biotechnology Research Centre, Tehran Medical Science, Islamic Azad University, Tehran, Iran

Source: Biotechnology Advances Published:2024


Abstract

Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity, shape memory, and configurability, they have been employed in autonomous molecular motors, logic circuits, reconfigurable nanoplatforms, and catalytic amplifiers. Moreover, the development of nucleic acid (NA)-responsive intelligent delivery vehicles is a rapidly growing field. These vehicles have attracted much attention in recent years due to their programmable, controllable, and reversible properties. In this work, we review several types of NA-responsive controlled delivery vehicles based on locks and keys, including DNA/RNA-responsive, aptamer-responsive, and CRISPR-responsive, and summarize their advantages and limitations. © 2024
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