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A Review of Recent Developments of Metal–Organic Frameworks As Combined Biomedical Platforms Over the Past Decade Publisher Pubmed



Moharramnejad M1, 2 ; Malekshah RE3, 4 ; Ehsani A1 ; Gharanli S5 ; Shahi M4 ; Alvan SA6 ; Salariyeh Z4 ; Azadani MN7 ; Haribabu J8 ; Basmenj ZS9 ; Khaleghian A10 ; Saremi H11 ; Hassani Z12 ; Momeni E10
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran
  2. 2. Young Researcher and Elite Group, University of Qom, Qom, Iran
  3. 3. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Chemistry, Semnan University, Semnan, Iran
  5. 5. Department of Chemical Engineering, Faculty of Engineering, Qom University, Qom, Iran
  6. 6. Bachelor of Chemical Engineering, Azad Varamin University, Peshwa branch, Iran
  7. 7. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. Facultad de Medicina, Universidad de Atacama, Los Carreras 1579, Copiapo, 1532502, Chile
  9. 9. Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Iran
  10. 10. Biochemistry Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  11. 11. Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Iran
  12. 12. Department of New Materials, Institute of Science, High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, 7631818356, Iran

Source: Advances in Colloid and Interface Science Published:2023


Abstract

Metal–organic frameworks (MOFs), also called porous coordination polymers, represent a class of crystalline porous materials made up of organic ligands and metal ions/metal clusters. Herein, an overview of the preparation of different metal-organic frameworks and the recent advances in MOF-based stimuli-responsive drug delivery systems (DDSs) with the drug release mechanisms including pH-, temperature-, ion-, magnetic-, pressure-, adenosine-triphosphate (ATP)-, H2S-, redox-, responsive, and photoresponsive MOF were rarely introduced. The combination therapy containing of two or more treatments can be enhanced treatment effectiveness through overcoming limitations of monotherapy. Photothermal therapy (PTT) combined with chemotherapy (CT), chemotherapy in combination with PTT or other combinations were explained to overcome drug resistance and side effects in normal cells as well as enhancing the therapeutic response. Integrated platforms containing of photothermal/drug-delivering functions with magnetic resonance imaging (MRI) properties exhibited great advantages in cancer therapy. © 2023
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