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Mof As Nanoscale Drug Delivery Devices: Synthesis and Recent Progress in Biomedical Applications Publisher



Moharramnejad M1, 2 ; Ehsani A1 ; Shahi M3 ; Gharanli S4 ; Saremi H5 ; Malekshah RE6 ; Basmenj ZS7 ; Salmani S7 ; Mohammadi M3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran
  2. 2. Young Researcher and Elite Group, Qom University, Qom, Iran
  3. 3. Department of Chemistry, Semnan University, Iran
  4. 4. Department of Chemical Engineering, Faculty of Engineering, University of Qom, Iran
  5. 5. Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Iran
  6. 6. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Iran
  7. 7. Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Iran

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

Metal-organic frameworks (MOFs) have received a lot of attention for application as nanoscale drug delivery devices due to their unique properties in high storage capacities, multiple functionalities, and excellent biocompatibilities. and abundant functionalities. Several strategies can be used to synthesise including traditional reactions (solvothermal or non-solvothermal methods), microwaves, electrochemistry, sonochemistry, mechanochemistry. MOFs are composed of metal ions/metal clusters linked by multitopic organic ligands containing sulfonate, carboxylate, and phosphonate groups. The various methods for modifying the surfaces of MOFs are described with covalent bonds and covalent bonds. The application of functional groups, MOFs are developed to produce high porous materials through covalent and non-covalent bonds. MOFs are used to encapsulate various drugs and other macromolecules including nucleic acids, DNA, siRNA and properties. © 2023
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