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Does Fibroblast Growth Factor 23 Correlates With Volume Status in Hemodialysis Patients? Publisher



Minoo F1, 2 ; Alamdari A1, 2 ; Karimi H1
Authors
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Authors Affiliations
  1. 1. Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Nephropathology Published:2019


Abstract

Introduction: Volume overload is a known risk factor for cardiovascular disease and stroke in hemodialysis patients. The use of fibroblast growth factor 23 (FGF23) as a volume overload marker has been validated in multiple studies. Objectives: This is a prospective cross-sectional study considering the association between FGF23 and bioimpedance-measured volume overload in hemodialysis patients. Patients and Methods: Bioimpedance analysis was performed on 43 hemodialysis patients at the end of hemodialysis to evaluate the remaining volume overload and serum FGF23 was measured before hemodialysis. Results: The results indicated no significant correlation between mean serum FGF23 levels and volume overload in hemodialysis patients (P = 0.824). Conclusion: Although this study did not show any association between volume overload and FGF23, further studies are needed to define the role of FGF23 as a volume overload marker. © 2019 The Author(s).