Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System

Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System Publisher

Mohammadian M¹ ; Jafarzadeh Kashi TS^{1, 2} ; Erfan M³ ; Soorbaghi FP⁴

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1. Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Polymer Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2018

Abstract

In the past years, use of aerogel in drug carrier systems has been of great interest among researchers because of its amorphous structure, significant porosity, and other special properties. In this study, the effects of physical characteristics of silica aerogels on the efficient medical application are investigated. To this end, silica aerogels with several densities were synthesized by using a two-stage sol-gel procedure and dilution by acetonitrile in gelation step. Physical characteristics of produced silica aerogels were analyzed by BET and BJH methods. Results reveal that the pore diameter and the surface area of silica aerogel are functions of its density. Using supercritical CO2 method, the efficiency of drug (Ketoprofen) loading on aerogels with respect to aerogel density was investigated. Cell viability and cell growth on silica aerogels were evaluated by MTT assay and SEM analysis, respectively. The drug-loaded materials were characterized by using of FT-IR, XRD, UV-Spectroscopy, and FE-SEM analysis. Results show that the effective density of silica aerogel for a drug carrier system is 0.12 g/cm3. © 2017 Elsevier B.V.

Experts (# of related papers)

Tahereh Sadat Jafarzadeh Kashi (1)

Style	Citing Format
MLA	Mohammadian M, et al.. "Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System." Journal of Drug Delivery Science and Technology, vol. 44, no. , 2018, pp. 205-212.
APA	Mohammadian M, Jafarzadeh Kashi TS, Erfan M, Soorbaghi FP (2018). Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System. Journal of Drug Delivery Science and Technology, 44(), 205-212.
Chicago	Mohammadian M, Jafarzadeh Kashi TS, Erfan M, Soorbaghi FP. "Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System." Journal of Drug Delivery Science and Technology 44, no. (2018): 205-212.
Harvard	Mohammadian M et al. (2018) 'Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System', Journal of Drug Delivery Science and Technology, 44(), pp. 205-212.
Vancouver	Mohammadian M, Jafarzadeh Kashi TS, Erfan M, Soorbaghi FP. Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System. Journal of Drug Delivery Science and Technology. 2018;44():205-212.
BibTex	@article{ author = {Mohammadian M and Jafarzadeh Kashi TS and Erfan M and Soorbaghi FP}, title = {Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System}, journal = {Journal of Drug Delivery Science and Technology}, volume = {44}, number = {}, pages = {205-212}, year = {2018} }
RIS	TY - JOUR AU - Mohammadian M AU - Jafarzadeh Kashi TS AU - Erfan M AU - Soorbaghi FP TI - Synthesis and Characterization of Silica Aerogel As a Promising Drug Carrier System JO - Journal of Drug Delivery Science and Technology VL - 44 IS - SP - 205 EP - 212 PY - 2018 ER -

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