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A Facile Route to the Synthesis of Anilinic Electroactive Colloidal Hydrogels for Neural Tissue Engineering Applications Publisher Pubmed



Zarrintaj P1 ; Urbanska AM2 ; Gholizadeh SS3 ; Goodarzi V4 ; Saeb MR5 ; Mozafari M6, 7, 8
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, United States
  3. 3. Department of Microbiology, College of Basic Science, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  4. 4. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Resin and Additives, Institute for Color Science and Technology, P.O. Box 16765-654, Tehran, Iran
  6. 6. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  7. 7. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
  8. 8. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Journal of Colloid and Interface Science Published:2018


Abstract

An innovative drug-loaded colloidal hydrogel was synthesized for applications in neural interfaces in tissue engineering by reacting carboxyl capped aniline dimer and gelatin molecules. Dexamethasone was loaded into the gelatin-aniline dimer solution as a model drug to form an in situ drug-loaded colloidal hydrogel. The conductivity of the hydrogel samples fluctuated around 10−5 S/cm which appeared suitable for cellular activities. Cyclic voltammetry was used for electroactivity determination, in which 2 redox states were observed, suggesting that the short chain length and steric hindrance prevented the gel from achieving a fully oxidized state. Rheological data depicted the modulus decreasing with aniline dimer increment due to limited hydrogen bonds accessibility. Though the swelling ratio of pristine gelatin (600%) decreased by the introduction and increasing the concentration of aniline dimer because of its hydrophobic nature, it took the value of 300% at worst, which still seems promising for drug delivery uses. Degradation rate of hydrogel was similarly decreased by adding aniline dimer. Drug release was evaluated in passive and stimulated patterns demonstrating tendency of aniline dimer to form a vesicle that controls the drug release behavior. The optimal cell viability, proper cell attachment and neurite extension was achieved in the case of hydrogel containing 10 wt% aniline dimer. Based on tissue/organ behavior, it was promisingly possible to adjust the characteristics of the hydrogels for an optimal drug release. The outcome of this simple and effective approach can potentially offer additional tunable characteristics for recording and stimulating purposes in neural interfaces. © 2018 Elsevier Inc.
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