Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Encapsulation: Controlled Drug Delivery Publisher



Farzin A1, 2 ; Beheshtizadeh N2, 3 ; Vaez A2, 4 ; Siminzar P2, 5 ; Varzandeh M2, 6 ; Azami M2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Isfahan, Iran
  3. 3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Source: Principles of Biomaterials Encapsulation: Volume 2 Published:2023


Abstract

Pharmaceutical researchers have been utilizing biomaterials over the last 40years to develop controlled drug delivery systems (DDSs). The reason for the extensive investigations on DDSs is that, without proper delivery, the majority of drugs are not adequately efficient and cause severe side effects. This chapter will first introduce drug release mechanisms, including diffusion, erosion, swelling, and osmosis. Then, there will be an investigation on the effect of polymer characteristics, such as crystallinity, molecular weight, hydrophilicity/hydrophobicity, polymer content, and pore-forming agents on the drug release kinetics of degradable and nondegradable polymers. Subsequently, an overview of targeted drug delivery by modification of DDS encapsulation will be summarized. Furthermore, smart drug deliveries will be discussed in detail, categorized by exogenous and endogenous stimuli. © 2023 Elsevier Ltd. All rights reserved.
Related Docs
View other Related Docs
1. Temperature-Responsive Smart Nanocarriers for Delivery of Therapeutic Agents: Applications and Recent Advances, ACS Applied Materials and Interfaces (2016)
2. Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (2015)
3. Controlled Anti-Cancer Drug Release Through Advanced Nano-Drug Delivery Systems: Static and Dynamic Targeting Strategies, Journal of Controlled Release (2020)
4. Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart internal stimulus-responsive nanocarriers for drug and gene delivery (2015)
5. Classification of Stimuli-Responsive Polymers As Anticancer Drug Delivery Systems, Drug Delivery (2015)
6. Smart Stimuli-Responsive Implantable Drug Delivery Systems for Programmed and On-Demand Cancer Treatment: An Overview on the Emerging Materials, Chemical Engineering Journal (2022)
7. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
8. Silk Fibroin Nanoparticle As a Novel Drug Delivery System, Journal of Controlled Release (2015)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (6)
Fatemeh Atyabi (5)
Other Related Docs
9. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
10. Recent Progress in the Application of Plant-Based Colloidal Drug Delivery Systems in the Pharmaceutical Sciences, Advances in Colloid and Interface Science (2022)
11. Emerging Biomedical Applications of Algal Polysaccharides, Current Pharmaceutical Design (2019)
12. Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review, International Journal of Nanomedicine (2020)
13. Micelle-Based Nanoparticles With Stimuli-Responsive Properties for Drug Delivery, Nanotechnology Reviews (2024)
14. Preparation and Evaluation of Doxorubicin-Loaded Pla–Peg–Fa Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (Spions) for Cancer Treatment: Combination Therapy With Hyperthermia and Chemotherapy, International Journal of Nanomedicine (2020)
15. Progress and Prospects of Magnetic Iron Oxide Nanoparticles in Biomedical Applications: A Review, Artificial Organs (2021)
16. Drug Release Behavior of Electrospun Twisted Yarns As Implantable Medical Devices, Biofabrication (2016)
17. Application of Nano-Based Systems for Drug Delivery and Targeting: A Review, Journal of Nanoparticle Research (2020)
18. Graphene-Based Nanomaterials for Stimuli-Sensitive Controlled Delivery of Therapeutic Molecules, Frontiers in Bioengineering and Biotechnology (2023)
19. Mesoporous Silica Nanoparticles As a Versatile Nanocarrier for Cancer Treatment: A Review, Journal of Molecular Liquids (2021)
20. Redox-Sensitive Smart Nanosystems for Drug and Gene Delivery, Current Organic Chemistry (2016)
21. Ignoring the Modeling Approaches: Towards the Shadowy Paths in Nanomedicine, Journal of Controlled Release (2018)
22. Synthesis of Hyaluronic Acid-Grafted Hollow Mesoporous Silica Nanoparticles As Nano-Carriers for Anticancer Drug Delivery, Journal of Nanoparticle Research (2022)
23. Ph-Sensitive Stimulus-Responsive Nanocarriers for Targeted Delivery of Therapeutic Agents, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2016)
24. Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and Biomems, Journal of Polymers and the Environment (2023)
25. Computational Analysis of Vincristine Loaded Silk Fibroin Hydrogel for Sustained Drug Delivery Applications: Multiphysics Modeling and Experiments, International Journal of Pharmaceutics (2021)
26. Synthesis and Characterization of Chitosan/Carbon Quantum Dots/Fe2o3 Nanocomposite Comprising Curcumin for Targeted Drug Delivery in Breast Cancer Therapy, International Journal of Biological Macromolecules (2023)
27. Aptamer-Modified Chitosan-Capped Mesoporous Silica Nanoparticles for Co-Delivery of Cytarabine and Daunorubicin in Leukemia, International Journal of Pharmaceutics (2023)
28. Agarose-Based Biomaterials for Advanced Drug Delivery, Journal of Controlled Release (2020)
29. Aptamer-Functionalized Chitosan-Coated Gold Nanoparticle Complex As a Suitable Targeted Drug Carrier for Improved Breast Cancer Treatment, Nanotechnology Reviews (2022)
30. Bacterial-Derived Biopolymers: Advanced Natural Nanomaterials for Drug Delivery and Tissue Engineering, TrAC - Trends in Analytical Chemistry (2016)
31. Triple-Negative Breast Cancer Treatment Meets Nanoparticles: Current Status and Future Direction, Journal of Drug Delivery Science and Technology (2022)
32. Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds, Frontiers in Chemistry (2022)
33. The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits, Contrast Media and Molecular Imaging (2020)
34. Controlled/Localized Release and Nanotechnology, Nanoengineered Biomaterials for Advanced Drug Delivery (2020)
35. Bioreactor Design-Assisted Bioprinting of Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery Applications, Bioprinting (2024)
36. Revisiting Structure-Property Relationship of Ph-Responsive Polymers for Drug Delivery Applications, Journal of Controlled Release (2017)
37. Smart Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery, Nanotechnology Reviews (2016)
38. Lipid-Based Nanoparticles for the Targeted Delivery of Anticancer Drugs: A Review, Current Drug Delivery (2022)
39. The Synthesis and Development of Poly(Ε-Caprolactone) Conjugated Polyoxyethylene Sorbitan Oleate-Based Micelles for Curcumin Drug Release: An in Vitro Study on Breast Cancer Cells, RSC Advances (2023)
40. Cross-Linked Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
41. Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to Be Aware Of, Current Pharmaceutical Biotechnology (2021)
42. Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2018)
43. Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv, AAPS PharmSciTech (2020)
44. Stimuli-Responsive Chitosan-Based Nanocarriers for Drug Delivery in Wound Dressing Applications: A Review, Carbohydrate Polymer Technologies and Applications (2024)
45. Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery, Gels (2020)
46. Graphene Aerogel Nanoparticles for In-Situ Loading/Ph Sensitive Releasing Anticancer Drugs, Colloids and Surfaces B: Biointerfaces (2020)
47. Polymeric Nanoparticles for Dna Vaccine-Based Cancer Immunotherapy: A Review, Biotechnology Letters (2023)
48. Functionalized Silk Fibroin Nanofibers As Drug Carriers: Advantages and Challenges, Journal of Controlled Release (2020)
49. Improving Curcumin Constraints With Ph-Responsive Chitosan Based Graphene Oxide/Montmorillonite Nanohybrid Modified Agarose in Breast Cancer Therapy, BioNanoScience (2024)
50. Assessment of Structural, Biological and Drug Release Properties of Electro-Sprayed Poly Lactic Acid-Dexamethasone Coating for Biomedical Applications, Biomedical Engineering Letters (2021)