Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dabrafenib Plus Trametinib in Low-Grade Versus High-Grade Gliomas: A Systematic Review and Meta-Analysis Publisher Pubmed



Hajikarimloo B1 ; Habibi MA2 ; Kooshki A3 ; Alvani MS4 ; Zare AH5 ; Hasanzade A4 ; Zare AH5 ; Akhlaghpasand M4 ; Tavanaei R4 ; Tos SM1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurological Surgery, University of Virginia, Charlottesville, VA, United States
  2. 2. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
  4. 4. Department of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neurological Surgery, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Cancer Published:2024


Abstract

Background: Dabrafenib plus trametinib is a novel targeted therapy for low-grade (LGG) and high-grade (HGG) gliomas. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of dabrafenib plus trametinib in LGG and HGG gliomas. Methods: The electronic databases of PubMed/Medline, Scopus, Embase, and Web of Science were searched from inception to 5 September 2024. The meta-analyses, sensitivity analysis, publication bias, and meta-regression were performed through the R program. Results: Nine studies with 313 patients were included. Our data demonstrated that dual blockage resulted in a pooled complete response (CR) rate of 10% (95% CI: 5—18%), partial response rate (PR) rate of 39% (95% CI: 32- 46%), stable disease (SD) rate of 36% (95% CI: 26-46%), and progressive disease (PD) rate of 17% (95% CI: 10- 29%). The PR was significantly higher in LGG (P = 0.03), and the PD was substantially lower in LGG (P < 0.01). Our results demonstrated a pooled overall objective response rate (ORR) of 47% (95% CI: 39—55%) without a significant difference in subgroups (P = 0.36). The meta-regression demonstrated that lower age, BRAF V600 mutation, longer dual blockage treatment duration, and history of prior resection were associated with more favorable outcomes in HGGs. Our meta-analysis revealed a pooled discontinuation due to adverse events (AE) rate of 12% (95% CI: 4- 31%). Conclusion: Dabrafenib plus trametinib is associated with favorable outcomes in gliomas, especially among those with lower age, BRAF V600 mutation, longer dual blockage treatment duration, and history of prior resection. The co-administration of dabrafenib and trametinib was associated with more favorable outcomes among LGGs than HGGs. © The Author(s) 2024.
Related Docs
View other Related Docs
1. Efficacy and Safety of Dabrafenib Plus Trametinib in Pediatric Versus Adult Gliomas: A Systematic Review and Meta-Analysis, Child's Nervous System (2025)
2. The Safety and Efficacy of Dabrafenib and Trametinib in Patients With Glioma: A Systematic Review and Meta-Analysis, European Journal of Clinical Pharmacology (2024)
3. Buckwheat and Cardiometabolic Health: A Systematic Review and Meta-Analysis, Journal of Personalized Medicine (2022)
4. Machine Learning Radiomics for H3k27m Mutation Prediction in Gliomas: A Systematic Review and Meta-Analysis, Neuroradiology (2025)
5. Reevaluating the Role of Heparin During Mechanical Thrombectomy for Acute Ischemic Stroke: Increased Risks Without Functional Benefit, Clinical Neurology and Neurosurgery (2024)
6. Effectiveness of Pay for Performance to Non-Physician Health Care Providers: A Systematic Review, Health Policy (2022)
7. Interferon Therapy in Patients With Sars, Mers, and Covid-19: A Systematic Review and Meta-Analysis of Clinical Studies, European Journal of Pharmacology (2021)
8. Sinus Node Dysfunction and Related Permanent Pacemaker Implantation After Major Cardiac Surgeries, Systematic Review, and Meta-Analysis, Frontiers in Cardiovascular Medicine (2023)
Experts (# of related papers)
View all Related Experts
Kaveh Hosseini (2)
Vafa Rahimi-Movaghar (2)
Other Related Docs
9. Human Studies of the Efficacy and Safety of Stem Cells in the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis, Stem Cell Research and Therapy (2024)
10. A Systematic Review and Meta-Analysis of Investigating the Mutual Impact of Covid-19 and Psoriasis: Focusing on Covid-19 Course in Psoriasis and the Opinion on Biologics in This Setting, Immunity# Inflammation and Disease (2023)
11. Low-Dose Whole Lung Irradiation for Treatment of Covid-19 Pneumonia: A Systematic Review and Meta-Analysis, International Journal of Radiation Oncology Biology Physics (2022)
12. Is Oral Consumption of Dates (Phoenix Dactylifera L. Fruit) in the Peripartum Period Effective and Safe Integrative Care to Facilitate Childbirth and Improve Perinatal Outcomes: A Comprehensive Revised Systematic Review and Dose-Response Meta-Analysis, BMC Pregnancy and Childbirth (2024)
13. Systematic Review Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials, Nutrients (2021)
14. Evaluating the Combination and Comparison of Ablative Fractional Lasers (Co2, Erbium-Yag) With Pulsed Dye Laser (Pdl) for Treating Hypertrophic Scars: A Systematic Review, Lasers in Medical Science (2025)
15. Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Catheter Ablation Vs. Standard Medical Therapy — a Systematic Review and Meta-Analysis, Heart Failure Reviews (2025)
16. A Systematic Review and Meta-Analysis of the Effectiveness of Perineural Dextrose Injection in Peripheral Compression Neuropathies of the Upper Limbs, Heliyon (2025)
17. Are Egfr Monoclonal Antibodies Associated With Clinical Benefits in Patients With Glioma: A Systematic Review, Meta-Analysis, and Specific Analysis on Glioblastoma and Diffuse Intrinsic Pontine Glioma, Neurosurgical Review (2025)
18. Middle Meningeal Artery Embolization Versus Conventional Management for Patients With Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis, Neurosurgery (2023)
19. The Effect of Interventions on Quality of Life, Depression, and the Burden of Care of Stroke Patients and Their Caregivers: A Systematic Review, Journal of Neuroscience Nursing (2025)
20. “Anatomic Patella Design Versus Medialized Dome Design in the Modern Posterior Stabilized (Attune) Total Knee Arthroplasty: A Systematic Review and Meta-Analysis”, Journal of Orthopaedic Surgery and Research (2025)
21. Are There Clinical Differences Between 3D-Printed and Milled Complete Dentures? a Systematic Review and Meta-Analysis, International Dental Journal (2025)
22. Vaginal Probiotics As Therapeutic Adjuncts for Improving Embryo Transfer Success Rates: A Systematic Review and Meta-Analysis, BMC Pregnancy and Childbirth (2025)
23. Interventions to Support Caregivers of Older Adults Undergoing Surgery: A Systematic Review, American Journal of Surgery (2025)
24. The Effects of Crocus Sativus (Saffron) on Adhd: A Systematic Review, Journal of Attention Disorders (2024)
25. Herbs As Old Potential Treatments for Lymphedema Management: A Systematic Review, Complementary Therapies in Medicine (2020)
26. Predictors of Outcome After Surgical Decompression for Mild Degenerative Cervical Myelopathy -A Systematic Review, Global Spine Journal (2024)
27. The Effectiveness of Universal Educational Interventions for Prevention of Illicit Drug Use Among University Students: A Systematic Review, Iranian Journal of Public Health (2024)
28. Impact of Antiviral Prophylaxis on Ebv Viremia and Posttransplant Lymphoproliferative Disorders in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis, Virology Journal (2025)