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Coenzyme Q10 in the Treatment of Heart Failure: A Systematic Review of Systematic Reviews Publisher Pubmed



Jafari M1, 2 ; Mousavi SM3 ; Asgharzadeh A3, 4 ; Yazdani N5
Authors
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Authors Affiliations
  1. 1. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Health Services Management Department, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  3. 3. School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Health Technology Assessment Group (HTAG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Heart Journal Published:2018


Abstract

Introduction: This article is an attempt to provide an overview of systematic reviews to determine the efficacy of CQ10 supplementation in the treatment of patients with cardiovascular diseases (CVD). Method and material: All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. Check references studies and the quality of the studies was assessed by means of AMSTTAR. No meta-analyses were performed due to the heterogeneity of studies. Result: Extracted data for Seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies. Conclusion: Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure. © 2018
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