Beneficial Effects of Coenzyme Q10 Supplementation on Lipid Profile and Intereukin‑6 and Intercellular Adhesion Molecule‑1 Reduction, Preliminary Results of a Double‑Blind Trial in Acute Myocardial Infarction Publisher



Mohseni M¹ ; Vafa M¹ ; Zarrati M¹ ; Shidfar F¹ ; Hajimiresmail SJ^{1, 2} ; Forushani AR³
Source: International Journal of Preventive Medicine Published:2015

Abstract

Background: The present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (MI) by supplementation with coenzyme Q10 (CoQ10). Methods: In a double‑blind, placebo‑controlled study, we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule‑1 [ICAM‑1]), serum concentration of intereukin‑6 (IL‑6) and lipid profiles (high‑density lipoprotein‑cholesterol [HDL‑C], low‑density lipoprotein‑cholesterol [LDL‑C], total cholesterol and triglyceride [TG]) in CoQ10 supplementation group (n = 26) compared with placebo group (n = 26) in hyperlipidemic patients with MI. Fifty‑two patients were randomized to receive 200 mg/day of CoQ10 or placebo for 12 weeks. Results: There were no significant differences for serum LDL‑C, total cholesterol, and TG between two mentioned groups after the intervention. A significant enhancement in serum HDL‑C level was observed between groups after the intervention (55.46 ± 6.87 and 44.07 ± 6.99 mg/dl in CoQ10 and placebo groups, respectively P< 0.001). Concentrations of ICAM‑1 (415.03 ± 96.89 and 453.38 ± 0.7 ng/dl CoQ10 and placebo groups, respectively, P = 0.001) and IL‑6 (11 ± 9.57 and 12.55 ± 8.76 pg/ml CoQ10 and placebo groups, respectively P = 0.001) in serum were significantly decreased in CoQ10 group. Conclusions: Supplementation with CoQ10 in hyperlipidemic patients with MI that have statin therapy has beneficial effects on their aspects of health. © 2015 Mohseni M.