Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Plga-Methionine Labeled Bodipy Nano-Conjugate for In-Vivo Optical Tumor Imaging Publisher



Shahroosvand Z1 ; Yeganeh NR3 ; Haddadian S2 ; Farzaneh J3 ; Ardestani MS3
Authors

Source: Applied Nanoscience (Switzerland) Published:2020


Abstract

Due to the high mortality rates of breast cancer-patients, early diagnosis of this disease is of great importance. Thus, researchers have investigated the application of molecular imaging with nano-particle-based probes to improve specificity and sensitivity of diagnostic imaging agent. Fluorescent dye molecules are imaging tools to make visible structures and functions of both normal and abnormal tissues. In this study, PLGA-methionine labeled with BODIPY FL nano-conjugated fluorescent was designed for breast cancer imaging. PLGA-methionine (nano-conjugate) was synthesized and the product was confirmed by fourier transform infrared, atomic force microscope and dynamic light scattering. In-vitro and in-vivo cytotoxicity tests were performed and results showed no toxicity on both cells and organs. In-vitro and in-vivo uptake detected by fluorescence presented acceptable accumulation in cancerous cells both in-vitro and in-vivo. Obtained results introduced a novel labeled nano-conjugate for breast cancer imaging. © 2020, King Abdulaziz City for Science and Technology.
Other Related Docs
9. Fluorescent Nanoclusters for Imaging of Cells/Stem Cells, Methods in Molecular Biology (2020)
14. Selective Immediate Detection of Cu2+ by a Ph-Sensitive Rhodamine-Based Fluorescence Probe in Breast Cancer Cell-Line, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy (2020)
16. Expected Years of Life Lost Due to Adult Cancer Mortality in Yazd (2004-2010), Asian Pacific Journal of Cancer Prevention (2016)
17. Targeted Gold Nanoparticles Enable Molecular Ct Imaging of Head and Neck Cancer: An in Vivo Study, International Journal of Biochemistry and Cell Biology (2019)
20. Gene Panel Testing in Hereditary Breast Cancer, Archives of Iranian Medicine (2020)