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Mxene and Prostate Cancer: Is There Promising News? Publisher Pubmed



Fattahi MR1 ; Baghlani M2 ; Eggener SE3 ; Dehghani M4 ; Khani MM5 ; Kajbafzadeh A6
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Biotechnology, Department of Basic Sciences, Islamic Azad University, Ahvaz, Iran
  3. 3. Section of Urology, University of Chicago, Chicago, IL, United States
  4. 4. Reza Radiotherapy and Oncology Center (RROC), Mashhad, Iran
  5. 5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell & Tissues Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2025


Abstract

Prostate cancer is the most prevalent cancer among men worldwide, and there have been many advances in its diagnosis and treatment. However, critical obstacles remain, including overdiagnosis, high rates of negative biopsies, management of side effects, and the timely detection of relapse. Despite these improvements, surgery and radiotherapy are still associated with a significant risk of short- or long-term side effects. MXenes are a novel class of two-dimensional nanomaterials manufactured through electrochemical procedures that accept a wide-termination of hydrophilic molecules as surface modifications. The importance of MXene has increased owing to many aspects, such as its high-gain synthesis potential, chemical flexibility, and high biocompatibility. Hence, MXene is a convenient nanomaterial that can be modified and synthesized in different models, suggesting its ability to improve screening, diagnosis, and theranostic applications, such as thermal therapy. These features have been used to detect potential urothelial tumor markers as well as the direction and accumulation of cancer medications in the target tissue. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
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