Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties

Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties Publisher Pubmed

Beik J¹ ; Alamzadeh Z¹ ; Mirrahimi M¹ ; Sarikhani A¹ ; Ardakani TS² ; Asadi M¹ ; Irajirad R¹ ; Mirrahimi M¹ ; Mahabadi VP^{4, 5} ; Eslahi N⁶ ; Bulte JWM^{7, 8} ; Ghaznavi H⁹ ; Shakerizadeh A¹

Show Affiliations

1. Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Physics, Payame Noor University, Tehran, Iran
3. Biology Department, School of Science, Tehran University of Medical Sciences, Tehran, Iran
4. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
5. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
6. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
7. Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University, School of Medicine, Baltimore, 21205, MD, United States
8. Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, School of Medicine, Baltimore, 21205, MD, United States
9. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Source: ACS Applied Bio Materials Published:2021

Abstract

The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy. © 2021 American Chemical Society.

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Style	Citing Format
MLA	Beik J, et al.. "Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties." ACS Applied Bio Materials, vol. 4, no. 5, 2021, pp. 4280-4291.
APA	Beik J, Alamzadeh Z, Mirrahimi M, Sarikhani A, Ardakani TS, Asadi M, Irajirad R, Mirrahimi M, Mahabadi VP, Eslahi N, Bulte JWM, Ghaznavi H, Shakerizadeh A (2021). Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties. ACS Applied Bio Materials, 4(5), 4280-4291.
Chicago	Beik J, Alamzadeh Z, Mirrahimi M, Sarikhani A, Ardakani TS, Asadi M, Irajirad R, et al.. "Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties." ACS Applied Bio Materials 4, no. 5 (2021): 4280-4291.
Harvard	Beik J et al. (2021) 'Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties', ACS Applied Bio Materials, 4(5), pp. 4280-4291.
Vancouver	Beik J, Alamzadeh Z, Mirrahimi M, Sarikhani A, Ardakani TS, Asadi M, et al.. Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties. ACS Applied Bio Materials. 2021;4(5):4280-4291.
BibTex	@article{ author = {Beik J and Alamzadeh Z and Mirrahimi M and Sarikhani A and Ardakani TS and Asadi M and Irajirad R and Mirrahimi M and Mahabadi VP and Eslahi N and Bulte JWM and Ghaznavi H and Shakerizadeh A}, title = {Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties}, journal = {ACS Applied Bio Materials}, volume = {4}, number = {5}, pages = {4280-4291}, year = {2021} }
RIS	TY - JOUR AU - Beik J AU - Alamzadeh Z AU - Mirrahimi M AU - Sarikhani A AU - Ardakani TS AU - Asadi M AU - Irajirad R AU - Mirrahimi M AU - Mahabadi VP AU - Eslahi N AU - Bulte JWM AU - Ghaznavi H AU - Shakerizadeh A TI - Multifunctional Theranostic Graphene Oxide Nanoflakes As Mr Imaging Agents With Enhanced Photothermal and Radiosensitizing Properties JO - ACS Applied Bio Materials VL - 4 IS - 5 SP - 4280 EP - 4291 PY - 2021 ER -

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