Spontaneous Sublingual Hematoma in a Covid-19 Patient on Heparin Therapy: A Case Report and Review of Management Challenges Publisher



Golkar M¹ ; Taheri A² ; Baseri M¹ ; Nikraftar P³ ; Ansari R¹ ; Khorsand A¹
Source: Case Reports in Medicine Published:2025

Abstract

COVID-19 is associated with a hypercoagulable state, often managed with anticoagulation therapy to prevent thrombotic events. However, anticoagulation can lead to rare but serious bleeding complications. We present the case of a 62-year-old male with severe COVID-19 admitted to the intensive care unit (ICU) with shortness of breath, cough, and oxygen desaturation. Also, he had diabetes, undergoing treatment with Neutral Protamine Hagedorn (NPH) insulin, and ischemic heart disease. On the eighth day of his admission, he developed a spontaneous sublingual hematoma while on unfractionated heparin therapy. The patient was managed conservatively with blood pressure control, cold compresses, adjustment of anticoagulation and close monitoring with laboratory anticoagulation tests, and careful observation. Despite the hematoma’s initial enlargement, he exhibited no respiratory distress, and the hematoma gradually resolved without surgical intervention. This case highlights the need for vigilant monitoring, careful management of anticoagulation, and a multidisciplinary approach in balancing the benefits and risks of anticoagulation in COVID-19 patients. Copyright © 2025 Mohsen Golkar et al. Case Reports in Medicine published by John Wiley & Sons Ltd.