Ferula Gummosa a Good Candidate to Promote Cutaneous Wound Healing Infected With Staphylococcus Aureus Publisher



Kalami S¹ ; Jooyan N² ; Ghodsian S³ ; Ghanbarpour O⁴ ; Daemi A⁵ ; Fardin M¹ ; Farahpour MR⁶ ; Hosseini ST⁷ ; Yousefi Y⁸ Show Affiliations
Source: Regenerative Engineering and Translational Medicine Published:2023

Abstract

Purpose: Staphylococcus aureus is one of the most important hospital pathogens (involving wound infections) that can become resistant against antibiotics. This study aims to investigate the effects of Ferula gummosa (FG) essential oil on this bacterium during wound healing. Methods: Ninety adult Wistar male rats were classified into five groups. After making wound in all rats, wound was infected by Staphylococcus aureus. Then, the control groups were treated with base ointment; and the third, fourth, and fifth groups were treated by base ointment containing 2%, 4%, and 8% of FG essential oil, respectively. On the 3rd, 7th, and 14th days, antimicrobial effects of FG essential oil against Staphylococcus aureus, as well as antioxidant biochemical factors, were tested on wound biopsies. Results: Antimicrobial test showed that FG essential oil caused decrement in Staphylococcus aureus infection. The levels of GSX, TAC, and SOD were significantly increased in FG essential oil–treated groups compared to the control group. Nevertheless, level of MDA was significantly less than that in treated groups in comparison to the control group. Conclusion: Ferula gummosa has an antimicrobial effect on Staphylococcus aureus, and its local application can enhance the antioxidant activity in wound. Lay summary: Ferula gummosa essential oil has antibacterial effects on skin infectious bacteria such as Staphylococcus aureus in vitro. Ferula gummosa has an antimicrobial effect on Staphylococcus aureus, and its local application can enhance the antioxidant activity in wound. It has locally been applied in the form of ointment and therapeutic doses. Staphylococcus aureus is one of the most important hospital pathogens (involving wound infections) that can become resistant against antibiotics. Increasing the levels of superoxide dismutase, glutathione peroxidase, and total antioxidant capacity as well as reducing of malondialdehyde and lipid peroxidation can inhibit cutaneous wound infected with Staphylococcus aureus, shorten the inflammatory phase, increase the proliferative phase, and increase the rate and quality of healing of infected wound in rats. Therefore, FG has been proposed to apply as antimicrobial agents with higher effect and lower toxicity in the cases of antibiotic resistance. However, more studies are needed to use it clinically. © 2023, The Author(s), under exclusive licence to The Regenerative Engineering Society.