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Comparative Evaluation of Probiotics Effects on Plasma Glucose, Lipid, and Insulin Levels in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Memarrast F1 ; Ghafourifard S2 ; Kolivand S1 ; Jafarynodooshan S1 ; Neyazi N3, 4 ; Sadroddiny E1 ; Motevaseli E5, 6
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Oncology, Kabul Medical University, Kabul, Afghanistan
  5. 5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Diabetes/Metabolism Research and Reviews Published:2017


Abstract

Background: Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. Daily consumption of probiotics, particularly Lactobacilli, has been proposed as a new strategy for prevention or control of diabetes. Methods: In the current study, the effects of various probiotics including Lactobacillus reuteri (L reuteri), Lactobacillus crispatus (L crispatus), and Bacillus subtilis on the levels of blood glucose, lipid, and insulin as well as haemoglobin A1c (HbA1c) were investigated in rat models of streptozotocin (STZ)-induced diabetes and compared with metformin. In addition, GLUT-4 and PPAR-γ transcript levels have been analysed in adipose tissues. Results: A significant decrease in plasma glucose and HbA1c levels and a dramatic increase in insulin levels have been detected after consumption of probiotics. Furthermore, lipid profiles have been improved. The expression of Glut-4 and Ppar-γ genes in adipose tissues also increased after treatment period. Conclusion: The results of this experiment showed that daily consumption of probiotics can be effective in control of STZ-induced diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.
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