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Higher Circulating Levels of Angptl8 Are Associated With Body Mass Index, Triglycerides, and Endothelial Dysfunction in Patients With Coronary Artery Disease Publisher Pubmed



Fadaei R1 ; Shateri H2 ; Distefano JK3 ; Moradi N4, 5 ; Mohammadi M2 ; Emami F5 ; Aghajani H6 ; Ziamajidi N2, 7
Authors
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Authors Affiliations
  1. 1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Diabetes and Fibrotic Disease Unit, Translational Genomics Research Institute, 445 N 5th Street, Phoenix, 85004, AZ, United States
  4. 4. Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  5. 5. Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Interventional Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Molecular and Cellular Biochemistry Published:2020


Abstract

Bac Coronary artery disease (CAD) is the leading cause of death worldwide and most commonly develops as a result of atherosclerosis. ANGPTL8 is a secreted adipokine that regulates lipid metabolism and is associated with cardiometabolic diseases, including type 2 diabetes and CAD. However, the association between circulating ANGPTL8 levels and CAD is inconsistent among studies and the mechanism by which ANGPTL8 contributes to CAD development remains poorly understood. Here we sought to evaluate the relationship between ANGPTL8 levels and endothelial dysfunction and adipose tissue inflammation in CAD patients. Concentrations of ANGPTL8, adiponectin, TNF-α, IL6, hsCRP, ICAM-1, and VCAM-1 were measured by ELISA in serum samples from 192 CAD patients diagnosed with stenosis > 50% in at least one coronary artery by angiography and 71 individuals with normal heart function. Serum ANGPTL8 levels were significantly higher in CAD patients compared to controls (83.84 ± 23.25 ng/mL vs. 50.45 ± 17.73; p < 0.001), independent of adjustment for age, sex, BMI, smoking and statin use. ANGPTL8 could also differentiate CAD patients from controls with 82.3% specificity and 81.4% sensitivity (p < 0.001). Adiponectin levels were lower in CAD patients, while ICAM-1, VCAM-1, TNF-α, IL6, and hsCRP levels were higher compared to non-CAD controls (all p < 0.001). ANGPTL8 levels were associated with BMI in controls and with BMI, TG, and ICAM-1 in CAD patients. The presence of elevated ANGPTL8 levels in CAD patients and independent association with TG and ICAM-1 suggest a possible role related to endothelial dysfunction in the pathogenesis of atherosclerosis. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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