Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Antidiabetic Effect of Quercetin: A Systematic Review and Meta-Analysis of Animal Studies Publisher Pubmed



Bule M1, 2, 3 ; Abdurahman A4 ; Nikfar S1, 5 ; Abdollahi M1, 6 ; Amini M1, 2
Authors
Show Affiliations
Authors Affiliations
  1. 1. The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia
  4. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Food and Chemical Toxicology Published:2019


Abstract

Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. The objective of this review is to provide a systematic evaluation of the evidence and a meta-analysis of data from previously published researches on the antidiabetic action of quercetin. A comprehensive literature search was conducted between July 2018 and August 2018 on PubMed, EMBASE, Web of Sciences and Scopus databases. A random-effects model was used to estimate the pooled effect size and studies were weighted according to an estimate of the mean difference. The heterogeneity between studies was assessed using a Higgins’ I2 test with corresponding p values. Overall 13 eligible articles with appropriate data on serum glucose were included in the statistical analysis. The meta-analysis for serum glucose level (mg/dL) showed that at doses of 10, 25 and 50 mg/kg there was a significant difference between the means. Therefore, the results of the meta-analysis support the hypothesis that quercetin lowers serum glucose level, at doses of 10, 25 and 50 mg/kg. © 2019 Elsevier Ltd
Experts (# of related papers)
Other Related Docs
48. Is Cotoneaster Manna Improving the Treatment of Neonatal Jaundice?, Bangladesh Journal of Pharmacology (2018)