Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Herbal and Nano-Based Herbal Medicine: New Insights Into Their Therapeutic Aspects Against Periodontitis Publisher



Rezaeitazangi F1 ; Mirhosseini AF2 ; Fathi A3 ; Roghanishahraki H4 ; Arefnezhad R5 ; Vasei F6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Fasa Univerity of Medical Sciences, Fasa, Iran
  2. 2. Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Avicenna Journal of Phytomedicine Published:2024


Abstract

Objective: Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle. Materials and Methods: This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases. Results: According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs. Conclusion: Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently. © 2024 Mashhad University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
2. Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review, Advances in Experimental Medicine and Biology (2021)
3. Exosomes Derived From Mesenchymal Stem Cells: Heralding a New Treatment for Periodontitis?, Tissue and Cell (2023)
4. Effect of Nano-Curcumin on Various Diseases: A Comprehensive Review of Clinical Trials, BioFactors (2023)
5. The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials, Advances in Experimental Medicine and Biology (2021)
6. C-Reactive Protein Levels in Chronic Gingivitis, Chronic Periodontitis and Periodontally Healthy Subjects, HealthMED (2012)
7. The Effect of Cucurbita Consumption on Non-Communicable Diseases, Cucurbita: Biology, Distribution and Habitat (2020)
8. Nanobiomaterials in Periodontal Tissue Engineering, Nanobiomaterials in Hard Tissue Engineering: Applications of Nanobiomaterials (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Bagherniya (11)
Gholamreza Askari (5)
Other Related Docs
9. The Antibacterial Effects of the Hydroalcoholic Extracts of Aloe Vera and Glycyrrhiza Glabra Against Cariogenic Bacteria Invitro, Journal of Babol University of Medical Sciences (2016)
10. Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis, Traditional and Integrative Medicine (2020)
11. Anti-Nanobacterial Therapy for Prevention and Control of Periodontal Diseases, Dental Hypotheses (2010)
12. A Comparative Evaluation of the Antimicrobial Effect of Chamomile, Aloe Vera-Green Tea, and Chlorhexidine Mouthwashes on Some Oral Bacterial Species, Dental Research Journal (2023)
13. The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A Grade-Assessed Systematic Review and Meta-Analysis of Clinical Trials, Antioxidants (2021)
14. Design, Formulation, and Physicochemical Evaluation of Periodontal Propolis Mucoadhesive Gel, Dental Research Journal (2016)
15. The Effects of Herbal Medicines on Cancer Therapy-Induced Oral Mucositis: A Literature Review, Phytotherapy Research (2022)
16. Antimicrobial Efficacy of Antiplaque Agents of Common Toothpastes Against Porphyromonas Gingivalis and Streptococcus Oralis: An in Vitro Study, Dental Research Journal (2024)
17. Local Delivery of Usnic Acid Loaded Rhamnolipid Vesicles by Gelatin / Tragacanth Gum / Montmorillonite/ Vanillin Cryogel Scaffold for Expression of Osteogenic Biomarkers and Antimicrobial Activity, Journal of Drug Delivery Science and Technology (2022)
18. Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials, Antioxidants (2020)
19. Phytosomal Curcumin: A Review of Pharmacokinetic, Experimental and Clinical Studies, Biomedicine and Pharmacotherapy (2017)
20. Exploring Curcumin's Healing Properties in the Treatment of Atopic Dermatitis, Food Bioscience (2024)
21. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)
22. The Effects of Nutraceuticals and Herbal Medicine on Candida Albicans in Oral Candidiasis: A Comprehensive Review, Advances in Experimental Medicine and Biology (2021)
23. The Antibacterial Activity of Nasturtium Officinale Extract on Common Oral Pathogenic Bacteria, Nigerian Journal of Clinical Practice (2022)
24. Clinical Trials, Patents, and Marketed Products of Nanocurcumin-Based Anticancer Drug Delivery Systems, Curcumin-Based Nanomedicines as Cancer Therapeutics (2024)
25. Review of Possible Mechanisms of Analgesic Effect of Herbs and Herbal Active Ingredient, Journal of Young Pharmacists (2017)
26. The Antimicrobial Effect of Doxycycline and Doped Zno in Tio2 Nanotubes Synthesized on the Surface of Orthodontic Mini-Implants, APOS Trends in Orthodontics (2022)
27. Association Between Periodontitis and Alzheimer's Disease: A Narrative Review, IBRO Neuroscience Reports (2025)
28. Effects of Curcuma, Black Pepper, and Ginger on the Pain and Performance of Patients With Chronic Knee Osteoarthritis, Journal of Health System Research (2020)
29. Antimicrobial Photodynamic Therapy With Dendrosomal Curcumin and Blue Laser Against Porphyromonas Gingivalis, Photodiagnosis and Photodynamic Therapy (2023)
30. The Efficacy of Oral Hydrogel Containing Hyaluronic Acid, Polyvinylpyrrolidone, and Glycyrrhizin for Prevention and Treatment of Oral Mucositis Induced by Chemotherapy, Journal of Isfahan Medical School (2021)
31. Herbal Formulation “Turmeric Extract, Black Pepper, and Ginger” Versus Naproxen for Chronic Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Clinical Trial, Phytotherapy Research (2020)
32. An Overview of the Uses of Propolis for Oral Health, Advancements in Life Sciences (2023)
33. Plant Extracts: Antioxidant and Antimicrobial Properties and Their Effect of Nanoencapsulation, Nanotechnology in Herbal Medicine: Applications and Innovations (2023)
34. Anti-Inflammatory and Wound Healing Activities of Aloe Littoralis in Rats, Research in Pharmaceutical Sciences (2012)
35. Periodontitis and Progression of Gastrointestinal Cancer: Current Knowledge and Future Perspective, Clinical and Translational Oncology (2023)
36. Effect of Propolis Mouthwash on Clinical Periodontal Parameters in Patients With Gingivitis: A Double-Blinded Randomized Clinical Trial, International Journal of Dental Hygiene (2022)
37. Pro-Inflammatory Cytokines May Associate Periodontitis With Pregnancy Complications: A Short Review, New Emirates Medical Journal (2024)
38. Preparation and Evaluation of Bioactive Bilayer Composite Membrane Phb/Β-Tcp With Ciprofloxacin and Vitamin D3 Delivery for Regenerative Damaged Tissue in Periodontal Disease, Journal of Applied Polymer Science (2022)
39. Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature, Antioxidants (2023)
40. Ferromagnetic Nickel (Ii) Oxide (Nio) Nanoparticles: Biosynthesis, Characterization and Their Antibacterial Activities, Rendiconti Lincei (2022)
41. The Efficacy of Herbal Medicine in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Clinical Trials, Phytotherapy Research (2022)
42. Comparative Effects of Premedication With Ibuprofen and Essential Oil of Urtica Dioica on Post-Endodontic Pain: Clinical Trial, Journal of Dentistry (Iran) (2024)
43. The Effects of Aloe Vera Against Gentamicin-Induced Tubular Toxicity, Journal of Isfahan Medical School (2016)
44. The Effect of Curcumin Supplementation on Clinical Factors in Patients With Rheumatoid Arthritis, Journal of Isfahan Medical School (2023)
45. Gingival Inflammatory Indices and Dental Stain Index After Using Aloe Vera-Green Tea Mouthwash, Matrica Mouthwash, or 0.2% Chlorhexidine Mouthwash Compared With Placebo in Patients With Gingival Inflammation, Open Dentistry Journal (2019)
46. Comparison of Topical Herbal Cream and 1% Clindamycin Gel for Treatment of Mild-To-Moderate Acne: A Randomized Clinical Trial, Jundishapur Journal of Natural Pharmaceutical Products (2022)
47. The Effectiveness of Elaeagnus Angustifolia Versus Curcumin in Osteoarthritis of the Knee - a Triple-Blind Randomized Clinical Trial, Journal of Isfahan Medical School (2022)
48. The Effects of Phytosomal Curcumin Supplementation on Clinical Symptoms, and Inflammatory and Oxidative Stress Biomarkers in Patients With Migraine: A Protocol for a Randomized Double-Blind Placebo-Controlled Trial, Avicenna Journal of Phytomedicine (2023)