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The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review Publisher Pubmed



Fakheran O1 ; Khademi A1 ; Bagherniya M2 ; Sathyapalan T3 ; Sahebkar A4, 5, 6
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Department of Periodontics, Dental Research Institute, Isfahan University of Medical sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  4. 4. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Advances in Experimental Medicine and Biology Published:2021


Abstract

The paper aims to review the current clinical evidence of various herbal agents as an adjunct treatment in the management of chronic periodontitis patients. Gingivitis and periodontitis are two common infectious inflammatory diseases of the supporting tissues of the teeth and have a multifactorial etiology. An important concern about chronic periodontitis is its association with certain systemic disease. New treatment strategies for controlling the adverse effects of chronic periodontitis have been extensively assessed and practiced in sub-clinical and clinical studies. It has been shown that the phytochemical agents have various therapeutic properties such as anti-inflammatory and antibacterial effects which can be beneficial for the treatment of periodontitis. The findings of this review support the adjunctive use of herbal agents in the management of chronic periodontitis. Heterogeneity and limited data may reduce the impact of these conclusions. Future long-term randomized controlled trials evaluating the clinical efficacy of adjunctive herbal therapy to scaling and root planing are needed. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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