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Thyroid Autoantibodies in Women With and Without Thyroid Disorders in an Iodine-Replete Area Pubmed



Aminorroaya A1 ; Momenzadeh M1 ; Hovsepian S1 ; Haghighi S1 ; Amini M1
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Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Eastern Mediterranean Health Journal Published:2008


Abstract

To compare the prevalence of positive autoantibodies in patients with thyroid disorders and healthy subjects in an iodine-replete area of the Islamic Republic of Iran, we studied 930 women in a clinic-based study: 698 patients (286 hypothyroid, 140 hyperthyroid, 272 with simple goitre) and 232 healthy women. Serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone, and antithyroid antibodies were measured. Positive autoantibodies were detected in 75.5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders.
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