Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Tooth Graft: An Umbrella Overview Publisher



Hashemi S1 ; Tabatabaei S2 ; Fathi A3 ; Asadinejad SM4 ; Atash R5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dental Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Public Health, Boston University, Boston, MA, United States
  3. 3. Dental Prosthodontics Department, Dental Materials Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Periodontology Department, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Prosthodontics, School of Dentistry, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium

Source: European Journal of Dentistry Published:2024


Abstract

This umbrella review aims to evaluate systematic/meta-analysis studies containing clinical evidence on tooth grafts as bone substitutes in the oral and maxillofacial regions. Using language restrictions and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, an electronic database search of PubMed, MEDLINE, Embase, Cochrane library, and Google Scholar was conducted, featuring published studies up until August 2022. All systematic/meta-analysis review articles relating to tooth graft materials were matched against the inclusion criteria. Two qualified researchers independently assessed the studies' inclusion or exclusion criteria and risk of bias, and a third investigator assisted in resolving ambiguities. A total of 81 systematic/meta-analysis studies, comprising 21 animal-controlled trials, 23 randomized controlled human trials, 23 prospective studies, and 14 retrospective studies, were selected for this study. A small risk of bias was observed in systematic studies/meta-analyses. In addition, the clinical evidence from the analysis of these studies revealed a low incidence of side effects. According to the current review, two systematic reviews indicated that autogenous bone grafting of prepared teeth might be as effective as other bone grafting materials. Four studies also mentioned autologous grafts as potential alternatives to autologous grafts, autogenous demineralized dentin (ADDM), engineered grafts, root blocks, and dental matrix. On the other hand, three systematic studies stated that more long-term research is needed to confirm their findings. Finally, given the importance of standardization and homogeneity of studies for clinical cases, it is advised to be used cautiously due to the risks of transplant rejection. © 2024 Georg Thieme Verlag. All rights reserved.
Related Docs
View other Related Docs
1. Bone Loss-Related Factors in Tissue and Bone Level Dental Implants: A Systematic Review of Clinical Trials, Journal of the Korean Association of Oral and Maxillofacial Surgeons (2021)
2. Treatment Options for Oral Rehabilitation of the Atrophic Maxilla: A Literature Review, Avicenna Journal of Dental Research (2023)
3. An Umbrella Review of Systematic Reviews and Meta-Analyses Evaluating the Success Rate of Prosthetic Restorations on Endodontically Treated Teeth, International Journal of Dentistry (2022)
4. The Anterior Palate As a Donor Site in Maxillofacial Bone Grafting: A Quantitative Anatomic Study, Journal of Oral and Maxillofacial Surgery (2005)
5. Attitude of Dental Students Toward Evidence-Based Dentistry in Iran: A Systematic Review, Dental Research Journal (2023)
6. Human Pulp Response to Direct Pulp Capping and Miniature Pulpotomy With Mta After Application of Topical Dexamethasone: A Randomized Clinical Trial, Iranian Endodontic Journal (2016)
7. Cone-Beam Computed Tomographic Comparison of Chin Symphysis Bone Particles and Allograft Versus Iliac Crest Bone Graft Alone for Reconstruction of Alveolar Bone Defects in Cleft Patients, Journal of the Korean Association of Oral and Maxillofacial Surgeons (2022)
8. Hard Tissue Formation in Pulpotomized Primary Teeth in Dogs With Nanomaterials Mcm-48 and Mcm-48/Hydroxyapatite: An in Vivo Animal Study, BMC Oral Health (2024)
Experts (# of related papers)
View all Related Experts
Amirhossein Fathi (11)
Sayed Mohammad Razavi (10)
Other Related Docs
9. A Comparison of Tissue-Engineered Bone From Adipose-Derived Stem Cell With Autogenous Bone Repair in Maxillary Alveolar Cleft Model in Dogs, International Journal of Oral and Maxillofacial Surgery (2013)
10. To Splint or Not to Splint Tooth and Adjacent Dental Implants: An Overview of Reviews, International Journal of Prosthodontics and Restorative Dentistry (2023)
11. Formulation of Treatment Plan in Pediatric Dental Implant Patients: A Systematic Review and Meta-Analysis, International Journal of Pharmaceutical Research (2019)
12. Effects of Chitosan As a Novel Obturation Material for Pulpectomized Teeth on Periapical Inflammation, Periodontal Ligament Widening, and Hard Tissue Resorption: A Preliminary Exploratory Study on Dogs, Frontiers in Dentistry (2024)
13. Calcium Phosphate Grafts Combined With Guided Tissue Regeneration in the Treatment of Periodontal Bony Defects- a Systematic Review and Meta-Analysis, Journal of Evidence-Based Dental Practice (2024)
14. Are There Clinical Differences Between 3D-Printed and Milled Complete Dentures? a Systematic Review and Meta-Analysis, International Dental Journal (2024)
15. A Randomized Controlled Clinical Trial Comparing Clinical and Radiographic Success Rates of Mta and Rhbmp2 in Pulpotomy of Primary Teeth, Frontiers in Dentistry (2024)
16. Enamel Matrix Derivatives As an Adjunct to Alveolar Ridge Preservation—A Systematic Review, Dentistry Journal (2023)
17. Investigation of the Effect of Fibrin Glue As a Sealant in the Unilateral Alveolar Bone Grafting Successes, Dental Research Journal (2023)
18. Long-Term Clinical Outcomes of Single Crowns or Short Fixed Partial Dentures Supported by Short (≤6 Mm) Dental Implants: A Systematic Review, European Journal of Dentistry (2024)
19. Management of Inflammatory Root Resorption of Maxillary Central Incisors Following Traumatic Avulsion, Case Reports in Dentistry (2021)
20. Edentulism and Tooth Loss in Iran, International Journal of Preventive Medicine (2012)
21. Reconstruction of Natural Smile and Splinting With Natural Tooth Pontic Fiber-Reinforced Composite Bridge, Case Reports in Dentistry (2022)
22. One-Year Clinical and Radiographic Assessment of Fluoride-Enhanced Implants on Immediate Non-Functional Loading in Posterior Maxilla and Mandible: A Pilot Prospective Clinical Series Study, Clinical Oral Implants Research (2011)
23. Significance of the Width of Keratinized Mucosa on the Health Status of the Supporting Tissue Around Implants Supporting Overdentures., The Journal of oral implantology (2009)
24. Comparison of the Outcomes and Complications of Three-Unit Porcelain-Fused-To-Metal Tooth-Implant-Supported Prostheses With Implant-Supported Prostheses: A Systematic Review and Meta-Analysis, Dental Research Journal (2023)
25. Adhesion to Zirconia: An Umbrella Review, International Journal of Adhesion and Adhesives (2023)
26. Does the Crown-Implant Ratio Affect the Survival and Complications of Implant-Supported Prostheses? a Systematic Review, Journal of Prosthetic Dentistry (2024)
27. Marginal Accuracy of Cad/Cam Frameworks Fabricated by Presintered Cobalt-Chromium Alloy: A Systematic Review and Meta-Analysis, International Journal of Oral and Maxillofacial Implants (2023)
28. Impact of Motivational Interviewing on Parental Risk-Related Behaviors and Knowledge of Early Childhood Caries: A Systematic Review, International Journal of Preventive Medicine (2021)
29. Effects of Impression Coping Design, Impression Technique, and Dental Undercuts on the Accuracy of Implant Impressions Assessed by 3-Dimensional Optical Scanning: An in Vitro Study, Implant Dentistry (2016)
30. Evaluation of Three Restorative Techniques for Primary Anterior Teeth With Extensive Carious Lesions: A 1-Year Clinical Study, Journal of Dentistry for Children (2013)
31. The Effects of Splinting Periodontally Compromised Removable Partial Denture Abutments on Bone Stresses: A Three-Dimensional Finite Element Study, Journal of Dental Sciences (2010)
32. Average Annual Crestal Bone Loss of Iti Implants Following the First Year of Loading, Journal of Research in Medical Sciences (2006)
33. Improving Pulp Revascularization Outcomes With Buccal Fat Autotransplantation, Journal of Tissue Engineering and Regenerative Medicine (2020)
34. A Comparative Study of Fracture Resistance of Endodontically Treated Compromised Teeth With Different Post Systems: An in Vitro Study, Open Dentistry Journal (2023)
35. The Association Between Mode of Childbirth Delivery and Early Childhood Caries: A Comprehensive Systematic Review and Meta-Analysis, PLoS ONE (2024)
36. Effects of Immediate Orthodontic and Orthopedic Forces on Peri-Miniscrew Bones: Histomorphologic and Histomorphometric Assessment in Dogs, International Journal of Dentistry (2012)
37. Efficacy of Acellular Dermal Matrix in Soft Tissue Augmentation Around Dental Implants: A Systematic Review and Meta-Analysis, Journal of Oral Implantology (2023)
38. Investigation of Peri-Implant Bone Healing Using Autologous Plasma Rich in Growth Factors in the Canine Mandible After 12 Weeks: A Pilot Study, Open Dentistry Journal (2011)
39. Effectiveness of Buccal Pouch Grafting in Minimizing Loss of Alveolar Dimension: A Canine Investigation, Dental Research Journal (2019)
40. Fabrication and Evaluation of Amalgam/Nano Hydroxyapatite Composites for Dental Restoration, Materials Research Express (2018)
41. Effect of Buccal Fat Autotransplantation on Improving the Alveolar Socket Bone Regeneration: An In-Vivo Study, Heliyon (2024)
42. Relation of Cad/Cam Zirconia Dental Implant Abutments With Periodontal Health and Final Aesthetic Aspects; a Systematic Review, Journal of Clinical and Experimental Dentistry (2023)
43. Pulp Response Following Direct Pulp Capping With Dentin Adhesives and Mineral Trioxide Aggregate; an Animal Study, Iranian Endodontic Journal (2017)
44. Mineral Trioxide Aggregate (Mta) and Calcium Hydroxide As Pulp-Capping Agents in Human Teeth: A Preliminary Report, International Endodontic Journal (2003)
45. Determine the Efficacy of Antibiotic Prophylaxis and Specific Antibiotic Regimens in Dental Implant Placement for the Prevention of Postoperative Infection (Poi) in Children: A Systematic Review and Meta-Analysis, International Journal of Pharmaceutical Research (2020)
46. Comparison of Oral Indices in Patients With Down Syndrome and Healthy Individuals: A Meta-Analysis Study, Dental Research Journal (2023)
47. The Present and Future Status of Oral and Maxillofacial Pathology in Iran:A Multicenter Study, Dental Research Journal (2023)
48. Functional Treatment of Skeletal Class Ii Malocclusion Using Bone-Anchored Devices and Intermaxillary Elastics, Dental Hypotheses (2015)
49. Anaesthetic Efficacy of Incorporating Different Additives Into Lidocaine for the Inferior Alveolar Nerve Block: A Systematic Review With Meta-Analysis and Trial Sequential Analysis, International Endodontic Journal (2022)
50. Clinical Outcomes of Dental Implants Placed in the Augmented Maxillary Sinus:A 5‑Year Retrospective Study, Dental Research Journal (2025)