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Brain-Derived Neurotrophic Factor (Bdnf) As a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis Publisher Pubmed



Hasani F1, 2 ; Masrour M3 ; Khamaki S1, 2 ; Jazi K4 ; Ghoodjani E5 ; Teixeira AL6
Authors
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Authors Affiliations
  1. 1. Gastroenterology and Hepatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Faculty of Medicine, Medical University of Qom, Qom, Iran
  5. 5. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Biggs Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Source: Brain and Behavior Published:2025


Abstract

Background: This systematic review and meta-analysis evaluates peripheral and CNS BDNF levels in glioma patients. Methods: Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we conducted quality assessment, meta-analysis, and meta-regression. Results: Eight studies were included. Meta-analysis showed significantly reduced plasma BDNF levels in glioma patients versus controls (SMD: −1.0026; 95% CI: [−1.5284, −0.4769], p = 0.0002). High-grade gliomas had lower plasma BDNF (p = 0.0288). Tissue BDNF levels were higher in glioma patients (SMD: 1.9513; 95% CI: [0.7365, 3.1661], p = 0.0016) and correlated with tumor grade (p = 0.0122). Plasma BDNF levels negatively correlated with patient age (p = 0.0244) and positively with female percentage (p = 0.0007). Conclusion: BDNF is a promising biomarker in glioma, showing significant changes in plasma and tissue levels correlating with tumor grade, patient age, and gender. © 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.
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