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Curcumin Delivery Via Dialdehyde Carboxymethyl Cellulose/Caco3/Gdl Cross-Linked Alginate Hydrogels for Wound Healing Publisher Pubmed



M Shafieiuon MARYAM ; Mh Enayati M H ; M Ghasemi MAEDE ; H Rostamabadi HADIS
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Source: International Journal of Biological Macromolecules Published:2025


Abstract

The development of advanced wound dressings is crucial for enhancing wound healing. This study introduces a novel sodium alginate (SA) emulsion gel cross-linked through both hemiacetal and ionic interactions using dialdehyde carboxymethyl cellulose (DCMC) and CaCO3. The emulsion gel encapsulates curcumin (CU) in a tunable, interconnected porous network controlled by DCMC concentration. The biocompatible emulsion gel demonstrated excellent shape memory and flexibility, maintaining its structure during movement. In vivo results showed a significant acceleration in wound closure, with an 85.0 ± 5.12 % reduction by day 12, compared to 18.97 ± 5.43 % in the control group. Histopathological analysis revealed reduced inflammation, attributed to the emulsion gel's antioxidant and antibacterial properties. This innovative system with antioxidant and wound healing properties provides a promising approach to advanced wound care, addressing the limitations of traditional dressings and enhancing hydrogel performance in wound healing. © 2025 Elsevier B.V., All rights reserved.
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