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Single Nucleotide Polymorphism Rs10889677 in Mirnas Let-7E and Let-7F Binding Site of Il23r Gene Is a Strong Colorectal Cancer Determinant: Report and Meta-Analysis Publisher Pubmed



Mosallaei M1 ; Simonian M1 ; Esmaeilzadeh E2 ; Bagheri H1 ; Miraghajani M3 ; Salehi AR1 ; Mehrzad V4 ; Salehi R1, 5
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Neuroscience Research Center, Iran University of Medical Science, Tehran, Iran
  3. 3. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Gerfa Namayesh Azmayesh (GENAZMA) Science & Research Institute, Isfahan, Iran

Source: Cancer Genetics Published:2019


Abstract

Single nucleotide polymorphisms (SNPs) in the recognition sites of microRNAs (miRNAs), located at 3′ untranslated region (UTR) of mRNAs, interfere with posttranslational gene regulation. Deregulation of genes may contribute to some disease susceptibility including colorectal cancer (CRC). In the present study, in a case-control setup, 167 CRC patients and 161 control subjects were studied for allele and genotype frequency of rs10889677 polymorphism in miRNAs Let-7e and Let-7f binding sites at 3′ UTR of IL23R gene using PCR–RFLP assay. Also, related articles were retrieved from MEDLINE, Cochrane review, Google Scholar and Scopus databases for meta-analysis study. According to our results, AA genotype of SNP rs10889677 was significantly correlated with increased risk of CRC (OR = 3.10; 95% CI [1.86–5.18]; P: < 0.001). In a meta-analysis on 10 risk estimates for the CC versus AA genotype, we found an inverse association between CC SNPs and risk of all cancer (OR = 0.59; 95% CI [0.49–0.71]; P < 0.001). In conclusion, our results demonstrate that rs10889677 polymorphism is significantly associated with CRC risk. © 2019 Elsevier Inc.
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