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Single Nucleotide Polymorphism Rs696 in Mir449a Binding Site of Nfkbia Gene Is Correlated With Risk of Colorectal Cancer Publisher



Simonian M1 ; Mosallayi M1 ; Miraghajani M2 ; Feizi A3 ; Khosravi S1 ; Salehi AR1 ; Mortazavi D1 ; Saberi F1 ; Salehi R1, 4, 5
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Gerfa Namayesh Azmayesh (GENAZMA) Science and Research Institute, Isfahan, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2018


Abstract

Aim: In present study we have elucidated the role of 2758 A>G (rs696), in the recognition site of miR449a in the 3' UTR of NFKB inhibitor alpha (NFKBIA) gene, in development of sporadic colorectal cancer. Background: Colorectal cancer (CRC) is rated as second cause of cancer death. Genetic determinants are considered as driving forces in development of sporadic CRC. Single nucleotide polymorphisms (SNPs), are attributed as the main genetic factor in cancers susceptibility. MicroRNAs, are key players in post-translational gene regulation by binding to their specific recognition sequences located at 3' untranslated region (UTR) of mRNAs. Methods: A case-control study using 143 CRC patients and 137 noncancerous counterparts were undertaken in order to determine rs696 genotypes using polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Results: There was a significant difference for the genotype frequencies of rs696 between patients and controls. The frequencies of GG, AG, AA genotypes in the control group were 38.7, 45.3, and 16.1 %, respectively, and the genotype frequencies in case group were 19.6, 40.6, and 39.9 %, respectively. Conclusion: Our results suggest significant correlation between rs696 polymorphism and colorectal cancer risk. © 2018 RIGLD.
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