Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Comprehensive Consolidation of Data on the Relationship Between Irf6 Polymorphisms and Non-Syndromic Cleft Lip/Palate Susceptibility: From 79 Case-Control Studies Publisher Pubmed



Golshantafti M1 ; Dastgheib SA2 ; Bahrami R3 ; Aarafi H1 ; Foroughi E4 ; Mirjalili SR5 ; Kheirandish N6 ; Aghasipour M7 ; Shiri A8 ; Azizi S9 ; Aghili K10 ; Manzourolhojeh M5 ; Neamatzadeh H5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Pediatric Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, United States
  8. 8. Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Radiology, Shahid Rahnemoon Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Journal of Stomatology, Oral and Maxillofacial Surgery Published:2024


Abstract

Background: Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a prevalent craniofacial birth defect on a global scale. A number of candidate genes have been identified as having an impact on NSCL/P. However, the association between interferon regulatory factor 6 (IRF6) polymorphisms and NSCL/P has yielded inconsistent results, prompting the need for a meta-analysis to obtain more accurate estimates. Methods: We conducted a thorough screening of all relevant articles published up until November 15, 2023, in online bibliographic databases. The statistical analysis of the collected data was performed using the Comprehensive Meta-Analysis (Version 4.0) software. Results: A total of 79 case-control studies, comprising 14,003 cases and 19,905 controls, were included in our analysis. The combined data indicated that the IRF6 rs642961 and rs2235371 polymorphisms were associated with an increased risk of NSCL/P in the overall population. However, no significant association was found between the rs2013162 and rs2235375 polymorphisms and the risk of NSCL/P in the overall population. Furthermore, subgroup analyses revealed significant correlations between the IRF6 rs642961, rs2235371, and rs2235375 polymorphisms and the risk of NSCL/P based on ethnic background and country of origin. Nevertheless, the rs2013162 polymorphism plays a protective role in Caucasians and mixed populations. Conclusions: Our collective data indicates a significant association between the rs642961 and rs2235371 polymorphisms and the risk of NSCL/P in the overall population. The rs2235375 polymorphism could influence the susceptibility to NSCL/P based on ethnic background. Meanwhile, the rs2013162 polymorphism provides protective effects in Caucasian, mixed populations, and the Brazilian population. © 2024 Elsevier Masson SAS
Related Docs
View other Related Docs
1. Family-Based Association Analysis Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6 Polymorphism in an Iranian Population, Clinical Oral Investigations (2015)
2. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molecular Biology (2015)
3. Incidence of Cleft Lip and Palate in Iran, a Meta-Analysis, Saudi Medical Journal (2011)
4. Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations, International Journal of Immunopathology and Pharmacology (2019)
5. Assessment of the Correlation Between Various Risk Factors and Orofacial Cleft Disorder Spectrum: A Retrospective Case-Control Study, Maxillofacial Plastic and Reconstructive Surgery (2020)
6. Possible Effect of Snail Family Transcriptional Repressor 1 Polymorphisms in Non-Syndromic Cleft Lip With or Without Cleft Palate, Clinical Oral Investigations (2018)
7. Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway, Archives of Oral Biology (2016)
8. Ultra-Rare Variants Identify Biological Pathways and Candidate Genes in the Pathobiology of Non-Syndromic Cleft Palate Only, Biomolecules (2023)
Experts (# of related papers)
View all Related Experts
Fatemeh Derakhshandeh (7)
Hossein Abdali (5)
Other Related Docs
9. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molekuliarnaia biologiia (2015)
10. Outcomes of Primary Repair of Cleft Palate Using Sommerled Intravelar Veloplasty Associated With Velocardiofacial Syndrome, International Journal of Pediatric Otorhinolaryngology (2024)
11. Speech Outcomes After Palatal Closure in 3–7-Year-Old Children, Brazilian Journal of Otorhinolaryngology (2022)
12. Incidence of Velopharyngeal Insufficiency and Oronasal Fistulae After Cleft Palate Repair: A Retrospective Study of Children Referred to Isfahan Cleft Care Team Between 2005 and 2009, International Journal of Pediatric Otorhinolaryngology (2015)
13. The -592C>A Variation of Il-10 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study and In-Silico Analysis, Journal of Oral Biosciences (2021)
14. The Study of Speech Disorders and Middle Ear Diseases Following Primary Palatoplasty in Children With Cleft Palate, Journal of Isfahan Medical School (2011)
15. Submucous Cleft Palate: Therapeutic Needs at Different Ages, Koomesh (2020)
16. The Prevalence of Hypernasality After Primary Cleft Palate Surgery in Children, Journal of Isfahan Medical School (2012)
17. Evaluation of Common Col2a1 Gene Variants in Iranian Patients Suspected With Stickler Syndrome Type I, Journal of Research in Medical Sciences (2025)
18. The Prevalence of Hypernasality After Primary Cleft Palate Surgery in Children, Journal of Isfahan Medical School (2012)
19. Craniosynostosis in Isfahan, Iran: A Cross-Sectional Study, Journal of Maxillofacial and Oral Surgery (2023)
20. Mutation of Kisspeptin 1 Gene in Children With Precocious Puberty in Isfahan City, International Journal of Preventive Medicine (2015)