Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats Publisher



Shoghi E¹ ; Safari T^{1, 2} ; Niazi AA³ ; Niyazi P¹ ; Bagheri H⁴ ; Vahedi MM⁵ ; Hashemi R¹ ; Maghool F⁶ ; Chahkandi M⁷
Source: Journal of Advances in Medical and Biomedical Research Published:2024

Abstract

Background & Objective: Liver damage is a common complication of lithium (Li). The present study investigates the preventive role of MgSo4 and moderate-intensity training MIT on Li hepatotoxicity in male rats. Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations. Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05. Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function. © 2024, Zanjan University of Medical Sciences and Health Services. All rights reserved.