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Changes in Serum, Liver, and Brain High and Low Molecular Weight Alkaline Phosphatase Following Manganese Toxicity in Rats Publisher



Mirhashemi SM1 ; Moshtaghie AA2 ; Ani M2 ; Aarabi MH1
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Biochemistry and Nutrition Department, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Faculty of Pharmacy, Clinical Biochemistry Department, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Toxicological and Environmental Chemistry Published:2009


Abstract

The relationship between manganese (Mn) treatment and changes in the activities of serum, liver, and brain high and low molecular weight alkaline phosphatase (ALP) activity was investigated. Results obtained showed that every other day intrapritoneally injection of 175mmolkg 1 Mn to male rats for two consecutive weeks produced decreased levels of liver and brain ALP activity, while a serum enzyme activity was significantly elevated. Chronic exposure to 68.7mmol kg 1 Mn produced a significant fall in liver and brain levels of ALP activity and a rise in serum activity. Using gel filtration chromatography technique with sephacryl S300 showed that, in comparison to control, serum and liver homogenate from Mn-treated groups displayed a significant level of high molecular weight ALP, which might be considered as a potential biomarker for Mn toxicity. © 2009 Taylor & Francis.
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