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Investigation of Antimicrobial Susceptibility, Class I and Ii Integrons Among Pseudomonas Aeruginosa Isolates From Hospitalized Patients in Isfahan, Iran Publisher Pubmed



Faghri J1 ; Nouri S2 ; Jalalifar S1 ; Zalipoor M1 ; Halaji M3
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Microbiology, Clinical Laboratory of ALZAHRA Medical Center, Isfahan, Iran
  3. 3. Students Research Committee, Isfahan University of Medical Sciences, Hezar Jarib St, Isfahan, Iran

Source: BMC Research Notes Published:2018


Abstract

Objectives: The role of integrons in the transfer of antibiotic resistance is one of the important issues, therefore, this study is aimed to investigate antibiotic resistance pattern and prevalence of class 1 and 2 integrons in P. aeruginosa isolated. Results: Out of 72 confirmed P. aeruginosa isolates, 50% were from ICU patients. Antibacterial susceptibility pattern showed that isolates were most resistant to ceftazidime (76.4%) and colistin was the most effective antibiotic (100%) and molecular analysis of class I and II integrons showed 55.5% and 29.1% of isolates were positive, respectively and the proportions of MDR isolates were significantly higher among integron-positive isolates with 73.6% compared to negative isolates with 22.9%. Our results showed that there was a correlation among class 1 and 2 integrons with MDR P. aeruginosa isolates. According to the importance of integrons in acquisition and dissemination of antibiotics resistance genes, the performance of antibiotic surveillance programs and investigating the role of integrons is recommended to control the spreading of antibiotics resistance genes. © 2018 The Author(s).
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