Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Prevalence of Fluoroquinolone Resistant Genes in Clinical Isolates of Pseudomonas Aeruginosa of Plasmid Origin Isolated From Patients Admitted to Alzahra Hospital of Isfahan Publisher



Ataei B1 ; Javadi A2 ; Zarghami L3 ; Nikookar F3 ; Pourahmad M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Infection Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Resident of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2022


Abstract

Background: Production of plasmid-dependent quinolone resistant proteins is a major problem in treating infections, but the effect of these proteins on antibiotic resistance has not been explored enough. Therefore, this study was performed to determine the frequency of these genes in clinical isolates of Pseudomonas aeruginosa in Al-Zahra Hospital of Isfahan. Methods: This cross-sectional study performed in Alzahra Hospital in Isfahan during 2019-2020. Cultures from 100 samples, positive for Pseudomonas aeruginosa were examined for the presence of qnrA, qnrB and qnrS genes by PCR and the frequency of this gene was assessed based on the ward and the source of the sample. Findings: Out of 100 Pseudomonas aeruginosa samples, 56 (56%) had at least one qnr gene. Thirteen of these samples contained two genes and one contained three qnr females. The frequency of gene based on hospital wards was significantly different (P < 0.001) but the number of genes based on hospital wards was not significantly different (P = 0.57). The frequency of qnrA in all samples was higher than qnrB and qnrS, but the type of gene did not differ significantly in terms of the sampling location (P = 0.36). Also, the frequency of the number of genes observed based on the sample source was not significantly different (P = 0.98). Conclusion: The findings of the present study indicate that the frequency of qnr genes in fluoroquinolone resistant (PMQR) samples in Pseudomodonas aeruginosa is high and this factor can lead to progressive antimicrobial resistance in different hospital wards. Therefore, it seems that the development of suitable antibiotic administration in hospitalized patients is an effective measure in controlling the spread of antibiotic resistance. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Emergence of Qnr-Resistance Among Klebsiella Pneumoniae Spp in Zahedan, Iranian Journal of Pharmaceutical Sciences (2018)
2. Molecular Epidemiology and Mechanisms of Antimicrobial Resistance in Pseudomonas Aeruginosa Isolates Causing Burn Wound Infection in Iran, Journal of Chemotherapy (2014)
3. Characterization of Toxin-Antitoxin (Ta) Systems in Pseudomonas Aeruginosa Clinical Isolates in Iran, Jundishapur Journal of Microbiology (2016)
4. Pseudomonas Aeruginosa Infections in Patients, Hospital Means, and Personnel's Specimens, Journal of Research in Medical Sciences (2012)
5. Clonal Relatedness Among Imipenem-Resistant Pseudomonas Aeruginosa Isolated From Icu-Hospitalized Patients, Critical Care Research and Practice (2015)
6. The Study of Mutation in Lasr and Pqsr Genes in Extremely Drug Resistant and Multidrug Resistant Strains of Pseudomonas Aeruginosa From Burn Wound Infection, Jundishapur Journal of Microbiology (2019)
7. Antibiotic Resistance Patterns and Genetic Diversity in Clinical Isolates of Pseudomonas Aeruginosa Isolated From Patients of a Referral Hospital, Isfahan, Iran, Jundishapur Journal of Microbiology (2015)
8. Rapid Monitoring of Pseudomonas Aeruginosa in Hospital Water Systems: A Key Priority in Prevention of Nosocomial Infection, FEMS Microbiology Letters (2013)
Experts (# of related papers)
View all Related Experts
Hossein Fazeli (18)
Sharareh Moghim (14)
Other Related Docs
9. Upstream Region of Oprd Mutations in Imipenem-Resistant and Imipenem-Sensitive Pseudomonas Isolates, AMB Express (2021)
10. Pattern of Antibiotic Resistance in Pesudomonas Aeruginosa Isolated From Intensive Care Unit, Isfahan, Iran, Journal of Isfahan Medical School (2013)
11. Incidence of Co-Resistance to Antibiotics and Chlorine in Bacterial Biofilm of Hospital Water Systems: Insights Into the Risk of Nosocomial Infections, Journal of Infection and Public Health (2023)
12. Assessment of Phage Cocktails With Extended Host Range Activity Against Antibiotic Resistant Strains of Pseudomonas Aeruginosa, Comparative Clinical Pathology (2017)
13. Global Sequence Analysis and Expression of Azurin Gene in Different Clinical Specimens of Burn Patients With Pseudomonas Aeruginosa Infection, Infection and Drug Resistance (2020)
14. The Effect of Isolated Bacteriophage on Multi-Drug Resistant (Mdr) Pseudomonas Aeruginosa, Journal of Isfahan Medical School (2014)
15. Antibiotic Resistance Pattern of Waterborne Causative Agents of Healthcare-Associated Infections: A Call for Biofilm Control in Hospital Water Systems, Journal of Infection and Public Health (2024)
16. Detection of Morphotyping Characteristics Identification Antibiotic Resistance of Pseudomonas Aeruginosa Isolated Form Cystic Fibrosis Patient, Journal of Isfahan Medical School (2012)
17. Investigation of Antimicrobial Susceptibility, Class I and Ii Integrons Among Pseudomonas Aeruginosa Isolates From Hospitalized Patients in Isfahan, Iran, BMC Research Notes (2018)
18. Occurrence of Chlorine-Resistant Pseudomonas Aeruginosa in Hospital Water Systems: Threat of Waterborne Infections for Patients, Antimicrobial Resistance and Infection Control (2024)
19. Identification of Beta-Lactamase-Producing Pseudomonas Aeruginosa With Multiple Antibiotic Resistances, Journal of Isfahan Medical School (2011)
20. Detection of Blactx-M15 and Blaoxa-48 Genes in Gram-Negative Isolates From Neonatal Sepsis in Central of Iran, Iranian Journal of Microbiology (2019)
21. Investigation of the Characteristics of Multidrug-Resistant (Mdr) Acinetobacter Baumannii Lytic Phage Isolated From the Intensive Care Unit, Journal of Isfahan Medical School (2019)
22. High Frequency of Integron-Associated Cassette Arrays Containing Dfra and Aad Genes in Urinary Isolates of Escherichia Coli in the Southwest of Iran, Molecular Genetics, Microbiology and Virology (2021)
23. Hospital Air: A Potential Route for Transmission of Infections Caused by Β-Lactam–Resistant Bacteria, American Journal of Infection Control (2016)
24. Systematic Review and Meta-Analysis on the Prevalence and Antibiotic Susceptibility Pattern in Pseudomonas Aeruginosa Isolated From Cystic Fibrosis Patients, Eurasian Journal of Medicine (2024)
25. Detection of Colistin Sensitivity in Clinical Isolates of Acinetobacter Baumannii in Iran, Journal of Research in Medical Sciences (2014)
26. Evolutionary Trajectories of Beta-Lactamase Ndm and Dlst Cluster in Pseudomonas Aeruginosa: Finding the Putative Ancestor, Pathogens and Global Health (2024)
27. Molecular Epidemiology of Colistin-Resistant Pseudomonas Aeruginosa Producing Ndm-1 From Hospitalized Patients in Iran, Iranian Journal of Basic Medical Sciences (2019)
28. Molecular Characterization and Phage Typing of Methicillin-Resistant Staphylococcus Aureus Isolated From Clinical Samples in Isfahan, Iran, Jundishapur Journal of Microbiology (2023)
29. The Bacterial Biofilm Resistome in Drinking Water Distribution Systems: A Systematic Review, Chemosphere (2023)
30. Characterization of Staphylococcus Epidermidis Isolates From Hospitalized Patients in Isfahan and Tehran Teaching Hospitals, Molecular Genetics, Microbiology and Virology (2014)
31. Clonal Repetitive Element Polymerase Chain Reaction Patterns of Pseudomonas Aeruginosa in Diabetic Foot Ulcers, Iran, IJID Regions (2025)
32. Investigating of Four Main Carbapenem-Resistance Mechanisms in High-Level Carbapenem Resistant Pseudomonas Aeruginosa Isolated From Burn Patients, Journal of the Chinese Medical Association (2018)
33. Heterogeneity in Resistant Fecal Bacteroides Fragilis Group Collected From Healthy People, Microbial Pathogenesis (2016)
34. Identification of Blaoxa−51−23−58, Blavim, Blandm, and Blaimp Carbapenemase Genes in Acinetobacter Baumannii Isolates From Hospitalized Patients, BMC Research Notes (2024)
35. Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus Aureus Due to Erm Genes, Iran, Iranian Journal of Microbiology (2014)
36. Prevalence and Molecular Identification of Antibiotic Resistant Airborne Bacteria at Intensive Care Units, Koomesh (2018)
37. Evaluation of Pseudomonas Aeroginosa Isolated From Cutaneous Infections and Determination of Drug Resistance Pattern in Patients of Alzahra Hospital in Esfahan, Journal of Isfahan Medical School (2010)
38. Epidemiology of Vim-1-Imipenem Resistant Pseudomonas Aeruginosa in Iran: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2014)
39. Investigation of Class I, Ii, and Iii Integrons Among Acinetobacter Baumannii Isolates From Hospitalized Patients in Isfahan, Iran, Oman Medical Journal (2018)
40. The Determination of Metallo-Beta-Lactamase Enzymes Prevalence in Pseudomonas Aeruginosa Using Etest and Their Antibiogram Patterns in Kermanshah, Iran, Journal of Kerman University of Medical Sciences (2015)
41. Antibacterial Resistance Patterns of Acinetobacter Baumannii Complex: The Results of Isfahan Antimicrobial Resistance Surveillance-1 Program, Asian Pacific Journal of Tropical Medicine (2021)
42. Occurrence of Airborne Methicillin-Resistant Staphylococcus Aureus in Different Hospital Wards, EnvironmentAsia (2019)
43. Genome Analysis of an Oxa-48-Producing Carbapenem- and Colistin-Resistant Klebsiella Pneumoniae Sequence Type 11 Clone Isolated From an Inpatient, Gene Reports (2021)
44. Co-Selection of Antibiotic and Disinfectant Resistance in Environmental Bacteria: Health Implications and Mitigation Strategies, Environmental Research (2025)
45. Different Virulence Capabilities and Ompa Expressions in St2 and St513 of Multidrug-Resistant Acinetobacter Baumannii, Current Microbiology (2019)
46. Resistotyping, Phenotyping and Genotyping of New Delhi Metallo-Β-Lactamase (Ndm) Among Gram-Negative Bacilli From Iranian Patients, Journal of Medical Microbiology (2017)
47. Determination of the Efflux Pump-Mediated Resistance Prevalence in Pseudomonas Aeruginosa, Using an Efflux Pump Inhibitor, Current Microbiology (2009)
48. Prevalence of Esbls and Biofilm Formation in Escherichia Coli Isolated From Urinary Tract Infection in Isfahan, Iran, Infection, Epidemiology and Microbiology (2022)
49. Evaluation of the Synergistic Effect of Tomatidine With Several Antibiotics Against Standard and Clinical Isolates of Staphylococcus Aureus, Enterococcus Faecalis, Pseudomonas Aeruginosa and Escherichia Coli, Iranian Journal of Pharmaceutical Research (2017)
50. Occurrence of Tetracycline Resistant Bacteria and Resistance Gene (Fetw) in Hospital and Municipal Wastewaters, Fresenius Environmental Bulletin (2014)