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Cytotoxic Evaluations of Iranian Conifers on Cancer Ells Publisher



Emami SA1 ; Sadeghialiabadi H1 ; Saeidi M2 ; Jafarian A3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pharmaceutical Biology Published:2005


Abstract

In this study, branchlets, fruit, or bark of Taxus baccata L. as well as branchlets or fruits of two other species of Iranian conifers, namely, Platycladus orientalis France and Cupressus sempervirens L. var. horizentalis (Mill) Gunde were collected, identified, and the cytotoxic effects of hydroalcoholic extracts on three human tumor cell lines were determined. Different concentrations of extracts were added to cultured cells and incubated for 72 h. Cell survival was evaluated using the MTT assay. Extracts from bark of female Taxus baccata showed inhibitory activities against Hela cells. The extracts of the branchlets of male and female T. baccata as well as obtained extract from fruits of P. orientalis showed inhibitory activities against MDA-MB-468 cells, whereas the extracts of branchlets of female T. baccata showed inhibitory activities against KB cells. In conclusion, obtained extract from bark of T. baccata showed comparable cytotoxic effect to doxorubicin against Hela cells. © 2005 Taylor & Francis Ltd.
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