Comparison of Interferon Beta Products and Azathioprine in the Treatment of Relapsing-Remitting Multiple Sclerosis Publisher Pubmed



Etemadifar M¹ ; Janghorbani M^{1, 2} ; Shaygannejad V¹ Show Affiliations
Source: Journal of Neurology Published:2007

Abstract

We compared the relative efficacy of interferon beta (IFNβ) products and azathioprine (AZA) in the treatment of relapsing- remitting multiple sclerosis (RRMS). Ninety-four previously untreated patients of short duration with RRMS were randomly allocated to the two treatment groups. The first group received IFNβ products (Betaferon,Avonex or Rebif); the second group received AZA for 12 months. Response to treatment was assessed at 3, 6, and 12 months after starting therapy. The mean number of relapse during one year of the study was lower in the AZA group than in the IFNβ products group (0.28 vs. 0.64, P < 0.05).After 12 months, 57.4% of patients receiving IFNβ products remained relapse free compared with 76.6% of those given AZA. The Expanded Disability Status Scale (EDSS) decreased by 0.30 units in IFNβ-treated patients (P < 0.05) and 0.46 in AZAtreated patients (P < 0.001). Treatment with IFNβ products and AZA significantly reduces the relapse rate and EDSS score in patients with RRMS, while AZA is more effective than the IFNβ formulations. © 2007 Steinkopff Verlag.