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High Dose Vitamin D Intake and Quality of Life in Relapsing-Remitting Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Ashtari F1 ; Toghianifar N2 ; Zarkeshesfahani SH3 ; Mansourian M4
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Isfahan University of Medical sciences, Isfahan, Iran
  2. 2. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biology, University Of Isfahan, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, Health School, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neurological Research Published:2016


Abstract

Background: Low level of vitamin D is associated with a more severe course and low quality of life in relapsing-remitting multiple sclerosis (RRMS). Low dose vitamin D intake has improved quality of life in RRMS patients. Objective: This study explored the effect of high dose vitamin D intake on quality of life in RRMS patients in a double blind randomized clinical trial. Methods: 94 RRMS patients were randomized to two groups. One group received 50,000 IU vitamin D3 every five days for 3 months. The other group received placebo. Interferon-β (IFN-β) continued as the main treatment in both groups. Quality of life was assessed using MSQOL-54 Persian version at the beginning and at the end of the study. Results: After 3 months, the vitamin D group had a significant difference in mental health composite with placebo group, 62.41 ± 13.99 vs. 60.99 ± 17.99 (p-value = 0.041). Change in health was 75.74 ± 25.73 and 70.59 ± 26.45 in vitamin D and placebo group, respectively (p-value = 0.036). Conclusions: Mental QOL improved significantly after taking high dose vitamin D for 3 months in vitamin D group relative to placebo. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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