Glucose and Lipid-Related Indicators in Relation to Elevated Alanine Aminotransferase in a Pediatric Population Publisher Pubmed

Summary: Research shows non-HDL cholesterol and related ratios predict elevated liver enzymes in kids, signaling fatty liver risk. #PediatricHealth #LiverHealth

Momeni A¹ ; Yazdi M¹ ; Motlagh ME² ; Qorbani M³ ; Kelishadi R¹
Source: Journal of Pediatric Endocrinology and Metabolism Published:2024

Abstract

Objectives: To determine the associations between various glucose and lipid-related indicators with elevated alanine aminotransferase (ALT) in pediatric population. Methods: We analyzed the cross-sectional data of 3,771 Iranian children and adolescents aged 7-18 years using the fifth survey of a national school-based surveillance program. The predictive power of 11 different glucose and lipid-related indicators for predicting elevated ALT was examined using receiver operating characteristic (ROC) curve. Results: In the total sample non-HDL-C, non-HDL-C/HDL-C, and TC/HDL-C showed the largest area under the curve (AUC) for elevated ALT detection, with 0.731 (cut-off, 129.5mg/dL), 0.706, and 0.706, respectively. In girls, non-HDL-C had the highest predictive value (AUC, 0.741, cut-off, 129.5mg/dL). Among boys, non-HDL-C/HDL-C and TC/HDL-C showed the largest AUC of 0.753 with optimum cut-off values of 2.63 and 3.63, respectively. Conclusions: The findings of this study suggest that non-HDL-C, non-HDL-C/HDL-C, and TC/HDL-C can be predictors of elevated ALT in the pediatric population. These indices can be useful in large population-based studies for predicting children and adolescents at risk of fatty liver. © 2024 Walter de Gruyter GmbH, Berlin/Boston.