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Association of Alanine Aminotransferase With Different Metabolic Phenotypes of Obesity in Children and Adolescents: The Caspian-V Study Publisher



Kelishadi R1 ; Hemati Z1 ; Qorbani M2, 3 ; Motlagh ME4 ; Djalalinia S5 ; Ahadi Z6 ; Shafiee G6 ; Mahdavi Gorabi A6 ; Rastad H7 ; Ziaodini H8 ; Daniali SS1 ; Heshmat R6
Authors
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Authors Affiliations
  1. 1. Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pediatrics Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  6. 6. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Bureau of Health and Fitness, Ministry of Education and Training, Tehran, Iran

Source: Frontiers in Endocrinology Published:2020


Abstract

Aim: To determine the association of alanine aminotransferase with different metabolic phenotypes of obesity in a nationally- representative sample of Iranian children and adolescents. Methods: This national study was conducted in the framework of the fifth survey of a national surveillance program entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease study. Participants consisted of 4,200 subjects aged 7–18 years, who were recruited by multistage random cluster sampling from 30 provinces in Iran. They were categorized to normal weight and obese groups and in each group those with and without MetS components. Results: Overall, 3,843 of participants completed the survey (response rate: 91.5%). Their mean (SD) age was 12.58 (3.15) years; 52.6% were boys, and 72.7% lived in urban areas. Mean of alanine aminotransferase (ALT) in subjects with abdominal obesity and general obesity was 8.81 (95% CI: 7.99–9.62) (IU/L) and 8.87 (95% CI: 7.28–10.46) (IU/L), respectively. According to the adjusted model, one unit increment in ALT increased odds of being metabolically non-healthy obese (MNHO) by 2% compared to metabolically healthy non-obese (MHNO) [adj.OR (95% CI): 1.02 (1.01–1.04)]. Also, subjects in the third and fourth quartiles of serum ALT had significantly greater odds of being MNHO than those in its first quartile [Q3/Q1: adj. OR (95% CI): 3.85 (1.70–8.71); Q4/Q1: Adj. OR (95% CI): 3.63 (1.51–8.73)]. Conclusion: This large population-based study revealed significant associations between metabolic phenotypes of obesity and ALT level. © Copyright © 2020 Kelishadi, Hemati, Qorbani, Motlagh, Djalalinia, Ahadi, Shafiee, Mahdavi Gorabi, Rastad, Ziaodini, Daniali and Heshmat.
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