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Cycloartanes From Euphorbia Aellenii Rech. F. and Their Antiproliferative Activity



Ayatollahi AM1 ; Ghanadian M2 ; Afsharypuor S3 ; Mesaik MA4 ; Abdalla OM4 ; Shahlaei M5 ; Farzandi G6 ; Mostafavi H6
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Authors Affiliations
  1. 1. School of Pharmacy and Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, I.R., Iran
  3. 3. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Welsh School of Pharmacy Centre for Socioeconomic Research, Cardiff University, United Kingdom

Source: Iranian Journal of Pharmaceutical Research Published:2011

Abstract

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity. © 2011 by School of Pharmacy.
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